Chapter 085. Neoplasms of the Lung (Part 4)
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Inherited Predisposition to Lung Cancer While an inherited predisposition to develop lung cancer is not common, several features suggest a potential for familial association. People with inherited mutations in RB (patients with retinoblastomas living to adulthood) and p53 (LiFraumeni syndrome) genes may develop lung cancer. First-degree relatives of lung cancer probands have a two- to threefold excess risk of lung cancer or other cancers, many of which are not smoking-related. An as yet unidentified gene in chromosome region 6q23 was found to segregate in families at high risk of developing lung cancer of all histologic types. Finally, certain polymorphisms...
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