Chapter 116. Immunization Principles and Vaccine Use (Part 10)
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An illuminating example is the case of Rotashield, a rhesus reassortant rotavirus vaccine, which was introduced for routine use in the United States in the late 1990s. Within 9 months of its introduction, cases of intussusception were reported by the CDC to be temporally associated with the administration of the initial vaccine dose. This report led first to the cessation of the vaccine's use and subsequently to its withdrawal from the market and the discontinuation of its production. The withdrawal of the vaccine in the United States made its use impossible in developing countries, where the risk of any...
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