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Circulating free insulin-like growth factor-I and prostate cancer: A case-control study nested in the European prospective investigation into cancer and nutrition
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Circulating total insulin-like growth factor-I (IGF-I) is an established risk factor for prostate cancer. However, only a small proportion of circulating IGF-I is free or readily dissociable from IGF-binding proteins (its bioavailable form), and few studies have investigated the association of circulating free IGF-I with prostate cancer risk.
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