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Decreased severity of experimental autoimmune arthritis in peptidylarginine deiminase type 4 knockout mice
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Peptidylarginine deiminase type 4 (PADI4) has been identified as a susceptibility gene for rheumatoid arthritis (RA) by genome-wide association studies. PADI4 is highly expressed in the bone marrow, macrophages, neutrophils, and monocytes.
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