Elution kinetics of vancomycin and gentamicin from carriers and their effects on mesenchymal stem cell proliferation: An in vitro study

Musculoskeletal infections remain a major complication in orthopedic surgery. The local delivery of antibiotics provides the high levels required to treat an infection without systemic toxicity. However, the local toxicity of antibiotic carriers to the mesenchymal stem cells, as a result of both the peak concentrations and the type of carrier, may be significant.