Epigenomics and transcriptomics of systemic sclerosis CD4+ T cells reveal longrange dysregulation of key inflammatory pathways mediated by disease-associated susceptibility loci

Systemic sclerosis (SSc) is a genetically complex autoimmune disease mediated by the interplay between genetic and epigenetic factors in a multitude of immune cells, with CD4+ T lymphocytes as one of the principle drivers of pathogenesis.