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Establishment of orthotopic osteosarcoma animal models in immunocompetent rats through muti-rounds of in-vivo selection
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Immunodeficient murine models are usually used as the preclinical models of osteosarcoma. Such models do not effectively simulate the process of tumorigenesis and metastasis. Establishing a suitable animal model for understanding the mechanism of osteosarcoma and the clinical translation is indispensable.
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