Evidence of acrolein in synovial fluid of dogs with osteoarthritis as a potential inflammatory biomarker

Acrolein is a known pro-inflammatory toxic aldehyde, propagating cellular damage and tissue inflammation in humans and animal models of various diseases. Osteoarthritis (OA) has a signifcant infammatory component; however, presence of acrolein in synovial fluid of joints with OA has not been previously reported.