Functional analysis of Flavonoid 3′,5′-hydroxylase from Tea plant (Camellia sinensis): Critical role in the accumulation of catechins

Flavonoid 3′,5′-hydroxylase (F3′5′H), an important branch point enzyme in tea plant flavan-3-ol synthesis, belongs to the CYP75A subfamily and catalyzes the conversion of flavones, flavanones, dihydroflavonols and flavonols into 3′,4′,5′-hydroxylated derivatives.