Generation of an 870 kb deletion encompassing the Skt/Etl4 locus by combination of inter- and intra-chromosomal recombination

In higher vertebrates the notochord is a transient rod-like structure in the midline of the embryo. In mouse embryos beginning at embryonic stage E8.5 the notochord arises as a distinct anatomical entity. Its anterior end is close to Radtke’s pouch from which it extends posteriorly to the tip of the tail.