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Genetic disruption of serine biosynthesis is a key driver of macular telangiectasia type 2 aetiology and progression
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Macular telangiectasia type 2 (MacTel) is a rare, heritable and largely untreatable retinal disorder, often comorbid with diabetes. Genetic risk loci subtend retinal vascular calibre and glycine/serine/threonine metabolism genes.
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