Type 2 diabetes

Type 2 diabetes mellitus (T2DM), especially those with complications, requires lifelong care and incurs substantial expenses. In order to reduce out-of-pocket costs borne by patients, understanding costs including direct non-medical cost is important. This study aims to examine direct non-medical cost and related factors among T2DM with complications.

9p vihatake 06-01-2025 0 0   Download

The rising burden of type 2 diabetes among multimorbidity patients poses a significant challenge, highlighting the need to identify self-care barriers and implement effective strategies to enhance glycemic control. This study aims to provide insights crucial for developing tailored behavioural interventions to improve diabetes management in primary care.

12p vihatake 06-01-2025 1 0   Download

Metformin is an oral antidiabetic drug from the biguanide class and it is the first-line drug chosen for the treatment of type 2 diabetes. This is a drug on the list of pharmaceutical substances required to report bioequivalence study data when registering the drug. Objectives: (1) To develope a capillary zone electrophoresis method for determining metformin hydrochloride in human plasma. (2) To validate the method.

10p viuchiha 03-01-2025 2 1   Download

This study aimed to determine the prevalence and associated factors of depression among outpatients with type 2 diabetes at the Endocrine Center in Quang Ngai Province, Vietnam. Methods: A cross-sectional study was conducted among 606 outpatients in 2019. Depression was assessed by using patient health questionnaire-9 (PHQ-9).

10p viuchiha 03-01-2025 2 0   Download

Bài giảng với các nội dung tổng quan về bệnh đái tháo đường; các thuốc điều trị đái tháo đường; phân tích gộp các nghiên cứu pha III về hiệu quả; hạ đường huyết... Mời các bạn cùng tham khảo bài giảng để nắm chi tiết nội dung.

45p kinhdovanhoa 09-09-2019 45 2   Download

The aim of the research "Relationship between depression, quality of life and foot ulcer healing rates in type 2 diabetic (T2D) patients" was: To determine if there is a relationship between depressive symptoms and the healing time of DFUs; to determine if there is a relationship between depressive symptoms, severity of T2D and the healing time of a DFU; to determine if there is a relationship between depressive symptoms on the QoL amongst people with a DFU.

105p runthenight04 02-02-2023 9 1   Download

Assessment the plantar pressure and some nerve conduction index, ankle-brachial index in type 2 diabetes patients. Evaluation the relation between the plantar pressure, nerve conduction index, ankle-brachial index and characteristics in type 2 diabetes patients.

30p angicungduoc6 21-07-2020 27 3   Download

Several new models have been implemented: evaluate the effect inhbitivity on hyperglycemic postprandial blood glucose of reagent in glucose/sucrose/starch tolerance test in normal and diabetic mice and the effect antagonism with insulin resistance in type 2 diabetic mice (the technique of "Hyperinsulinemic - euglycemic clamp test")

25p tamynhan0 15-06-2020 11 1   Download

Pioglitazone hydrochloride (PGH) is an oral anti-hyperglycemic agent used in the treatment of type-2 diabetes mellitus. Potassium permanganate was found to oxidize PGH both in acidic and basic conditions, based on which two simple and sensitive methods were developed for its determination in bulk sample and tablets, and validated.

12p tocectocec 25-05-2020 15 2   Download

Adult nesidioblastosis is characterized by endogenous hyperinsulinemia typically causing post-prandial hypoglycemia, and most commonly occurs post-Rouxen-Y gastric bypass.

5p caothientrangnguyen 09-05-2020 11 1   Download

Type 2 diabetes, Prevalence of type 2 diabetes, Risk factors for type 2 diabetes, Type 2 diabetes causes, Associated factors of type 2 diabetes

6p trieusuper 14-09-2018 35 0   Download

Human amylin (hA) is a small fibrillogenic protein that is the major con-stituent of pancreatic islet amyloid, which occurs in most subjects with type-2 diabetes mellitus (T2Dm). There is growing evidence that hA toxic-ity towards islet b-cells is responsible for their gradual loss of function in T2Dm. Preventing hA-mediated cytotoxicity has been proposed as a route to halt the progression of this disease, although this has not yet been dem-onstratedin vivo.

11p fptmusic 12-04-2013 31 2   Download

Metformin (1,1-dimethylbiguanide) is an antihyperglycae-mic drug used to normalize glucose concentrations in type 2 diabetes. Furthermore, antioxidant benefits have been reported in diabetic patients treated with metformin. This work was aimed at studying the scavenging capacity of this drug against reactive oxygen species (ROS) like Æ OH and O Æ
2 -free radicals. ROS were produced by gamma radio-lysis of water. The irradiated solutions of metformin were analyzed by UV/visible absorption spectrophotometry.

8p awards 05-04-2013 61 1   Download

Insulin resistance is a cardinal feature of type 2 diabetes and also a conse-quence of trauma such as surgery. Directly after surgery and cell isolation, adipocytes were insulin resistant, but this was reversed after overnight incu-bation in 10% CO2 at 37
C 2 . Tyrosine phosphorylation of the insulin receptor and insulin receptor substrate (IRS)1 was insulin sensitive, but protein kinase B (PKB) and downstream metabolic effects exhibited insulin resistance that was reversed by overnight incubation....

0p awards 05-04-2013 46 3   Download

The prolyl oligopeptidase (POP) family of serine proteases includes prolyl oligopeptidase, dipeptidyl peptidase IV, acylaminoacyl peptidaseandoligopeptidase B.The enzymes of this family specifically hydrolyze oligopeptides with less than 30 amino acids.Many of the POP family enzymes have evoked pharmaceutical interest as they have roles in the regulationof peptide hormones and are involved in a variety of diseases such as dementia, trypanosomiasis and type 2 diabetes.

11p dell39 03-04-2013 58 4   Download

Inhibition of the mitochondrial adenine nucleotide translocator (ANT) by long-chain acyl-CoA esters has been proposed to contribute to cellular dys-function in obesity and type 2 diabetes by increasing formation of reactive oxygen species and adenosine via effects on the coenzyme Q redox state, mitochondrial membrane potential (Dw) and cytosolic ATP concentrations.

15p inspiron33 23-03-2013 55 4   Download

Oxidative stress, followed by the apoptotic death of pancreaticbcells, is considered to be one of causative agents in the evolution of the type 2 dia-betic state; therefore, the protection ofbcells can comprise an efficacious strategy for preventing type 2 diabetes. In the present study, RIN-m5F cells (i.e. the rat insulinoma bcell line) were stimulated with streptozotocin, resulting in a time- and concentration-dependent release of lactate dehydrogenase.

10p vinaphone15 28-02-2013 33 2   Download

One of the most important pathological features of type 2 diabetes is the formation of islet amyloid, of which the major component is amylin pep-tide. However, the presence of a natural inhibitor such as insulin may keep amylin stable and physiologically functional in healthy individuals. Some previous studies demonstrated that insulin was a potent inhibitor of amylin fibril formationin vitro, but others obtained contradictory results.

7p viettel02 22-02-2013 41 3   Download

Sterol regulatory element-binding proteins 1 and 2 (SREBP-1 and SREBP-2) are important regulators of genes involved in cholesterol and fatty acid metabolism, but have also been implicated in the regulation of the cell cycle and have been associated with the pathogenesis of type 2 diabetes, atherosclerosis and obesity, among others.

13p viettel02 22-02-2013 37 3   Download

Lipocalin-type prostaglandin (PG) D synthase is expressed in adipose tissues and involved in the regulation of glucose tolerance and atherosclero-sis in type 2 diabetes. However, the physiological roles of PGD2 in adipo-genesisin vivo are not clear, as lipocalin-type prostaglandin D synthase can also act as a transporter for lipophilic molecules, such as retinoids.

10p mobifone23 18-01-2013 39 3   Download