Hemoglobin stimulates the expression of ADAMTS-5 and ADAMTS-9 by synovial cells: A possible cause of articular cartilage damage after intra-articular hemorrhage

ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) proteins play an important pathological role in matrix degeneration. Aggrecan degradation is a significant and critical event in early-stage osteoarthritis.