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Aggrecan degradation
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Aggrecan degradation is the hallmark of cartilage degeneration in osteoarthritis (OA), though it is unclear whether a common proteolytic process occurs in all individuals.
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vioregon2711
22-02-2021
5
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ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) proteins play an important pathological role in matrix degeneration. Aggrecan degradation is a significant and critical event in early-stage osteoarthritis.
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vitennessee2711
02-02-2021
6
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Three mammalian ADAMTS enzymes, ADAMTS-1, -4 and -5, are known to cleave aggrecan at certain glutamyl bonds and are considered to be largely responsible for car-tilage aggrecan catabolismobservedduring the development of arthritis. We have previously reported that certain cate-chins, polyphenolic compounds found in highest concen-trationingreentea(Camellia sinensis), are capable of inhibiting cartilage aggrecan breakdown in anin vitromodel of cartilage degradation.
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fptmusic
16-04-2013
29
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