Báo cáo khoa học: Selective inhibition of ADAMTS-1, -4 and -5 by catechin gallate esters

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:10

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Three mammalian ADAMTS enzymes, ADAMTS-1, -4 and -5, are known to cleave aggrecan at certain glutamyl bonds and are considered to be largely responsible for car-tilage aggrecan catabolismobservedduring the development of arthritis. We have previously reported that certain cate-chins, polyphenolic compounds found in highest concen-trationingreentea(Camellia sinensis), are capable of inhibiting cartilage aggrecan breakdown in anin vitromodel of cartilage degradation.We have nowclonedand expressed recombinant human ADAMTS-1, -4 and -5 and report here that the catechin gallate esters found in green tea potently inhibit the aggrecan-degrading activity of these enzymes, with submicromolar IC50 values....

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