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Báo cáo khoa học: Novel a-conotoxins from Conus spurius and the a-conotoxin EI share high-affinity potentiation and low-affinity inhibition of nicotinic acetylcholine receptors
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a-Conotoxins from marine snails are known to be selective and potent competitive antagonists of nicotinic acetylcholine receptors. Here we des-cribe the purification, structural features and activity of two novel toxins, SrIA and SrIB, isolated fromConus spuriuscollected in the Yucatan Chan-nel, Mexico.
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