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Human breast cancer and lymph node metastases express Gb3 and can be targeted by STxBvectorized chemotherapeutic compounds
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The B-subunit of Shiga toxin (STxB) specifically binds to the glycosphingolipid Gb3 that is highly expressed on a number of human tumors and has been shown to target tumor cells in mouse models and ex vivo on primary colon carcinoma specimen.
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