IMNI PRECISION trial protocol: A phase II, open-label, non-inferior randomized controlled trial of tailoring omission of internal mammary node irradiation for early-stage breast cancer

Since the publication of MA-20 and EORTC-22922 trials, chest wall (CW)/ whole breast (WB) irradia‑ tion+comprehensive regional nodal irradiation (RNI) with internal mammary node irradiation (IMNI) has been the standard adjuvant treatment for early-stage breast cancer (BC).