Interaction between the BAG1S isoform and HSP70 mediates the stability of antiapoptotic proteins and the survival of osteosarcoma cells expressing oncogenic MYC

The oncoprotein MYC has the dual capacity to drive cell cycle progression or induce apoptosis, depending on the cellular context. BAG1 was previously identified as a transcriptional target of MYC that functions as a critical determinant of this cell fate decision.