Labile crosslinked hyaluronic acid via urethane formation using bis(βisocyanatoethyl) disulphide with tuneable physicochemical and immunomodulatory properties

Here, we synthesise a new isocyanate-based crosslinker with the aim of obtaining novel tailored gels. The newly crosslinked hyaluronic acid (HA) gels were analysed in terms of rheological properties, chemical structure, swelling, biocompatibility and immunological response.