Master's thesis of Engineering: Experimental studies in aid of improving nasal drug delivery

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The nasal route for drug administration has the potential for local and systemic delivery of a wide variety of therapeutics. Nasal spray drug delivery has the potential to administer drugs to the bloodstream, avoiding the use of painful needles. While there is great potential, studies in the area are limited and somewhat conflicting. This study aimed to support the improvement of nasal drug delivery through experimental work on a model nasal cavity and through experimental characterisation of nasal spray behaviour. Four different brands of nasal spray were investigated. Particle distribution studies via laser diffraction and high speed videography were performed at three different actuation forces, representing the average adult, child and maximum force applied to the spray device.

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