Methylation pattern of repetitive elements in correlation with genome wide global DNA methylation in the prognosis of paediatric tuberculosis

Epigenetic modulation plays a vital role in regulating the transcriptional machinery of human genome in response to infection. Differential Methylation pattern of the genome especially the retro transposon repetitive elements (RE) which constitutes more than 45% of the genome had been studied to trace the impact of RE methylation in the disease severity. The correlation of the levels of genome wide DNA methylation and the methylation levels of LINE1 (Long interspersed transposable elements), SINE- Alu (Short interspersed transposable elements) repetitive elements (RE) showed the influence of repetitive elements in the prognosis of Mycobacterium tuberculosis among pediatric population.