Myokines related to leukocyte recruitment are down-regulated in osteosarcoma

Myokines are cytokines that are secreted by muscle cells during exercises, muscle development and pathology. Studies have shown that expression of some individual myokines was altered in tumors. However, comprehensive analyses of myokines’ expression in osteosarcoma (OS), the most common malignant tumor in musculoskeletal system, have not been performed.