Osteo-sarcoma
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The aim of this study was to investigate the clinical, imaging and pathological features of extraskeletal osteosarcoma (EOS) and to improve the understanding of this disease and other similar lesions.
10p vishanshan 27-06-2024 2 1 Download
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SRSF1, a member of Serine/Arginine-Rich Splicing Factors (SRSFs), has been observed to significantly influence cancer progression. However, the precise role of SRSF1 in osteosarcoma (OS) remains unclear. This study aims to investigate the functions of SRSF1 and its underlying mechanism in OS.
12p vishanshan 27-06-2024 1 1 Download
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Immunodeficient murine models are usually used as the preclinical models of osteosarcoma. Such models do not effectively simulate the process of tumorigenesis and metastasis. Establishing a suitable animal model for understanding the mechanism of osteosarcoma and the clinical translation is indispensable.
11p vishanshan 27-06-2024 1 1 Download
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The prognosis of patients with Relapsed/Refractory Osteosarcoma (R/R OS) remains dismal without an agreement on systemic therapy. The use of High-Dose Ifosfamide (14 g/sqm) with an external pump in outpatient setting (14-IFO) in R/R OS patients is limited. This study represents the first retrospective cohort analysis focused on evaluating the activity and toxicity of 14-IFO in this setting.
12p vikoch 27-06-2024 1 1 Download
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Osteosarcoma (OS) is one of the most common aggressive bone malignancy tumors in adolescents. With the application of new chemotherapy regimens, finding new and effective anti-OS drugs to coordinate program implementation is urgent for the patients of OS.
11p vikoch 27-06-2024 2 1 Download
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This study aims to identify functionally relevant lncRNAs impacting OS proliferation and lipid metabolism and seeks to shed light on the upstream regulatory mechanisms governing lipogenic enzyme activity. Based on comprehensive bioinformatic analysis and the establishment of a risk model, we identified seven lncRNAs signifcantly associated with clinical characteristics and lipid metabolism-related genes in patients with OS.
15p vikoch 27-06-2024 1 1 Download
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Ebook "Current advances in osteosarcoma" summarizes molecular and genetic characteristics, new therapeutic ideas, and biological characteristics that have been uncovered in the past 10 years. Osteosarcoma is an aggressive malignant neoplasm and it is also the most common histological form of bone cancer. It accounts for approximately 56% of new bone tumors, making it the most primary malignant bone tumor in children and adolescents.
358p tracanhphuonghoa1007 22-04-2024 6 1 Download
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Osteosarcoma arising from the bladder is extremely rare, with only 38 cases reported to our knowledge. It is often detected owing to hematuria, and is treated by surgery (for example, total cystectomy), radiation therapy, and chemotherapy; however, the prognosis is extremely poor.
5p vitiki 30-01-2024 2 2 Download
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Part 2 book "Animal oncology" includes content: Connective tissue (mesenchymal) tumours - fibroma and fibrosarcoma; lipoma and liposarcoma; myxoma and myxosarcoma; chondroma and chondrosarcoma; osteoma and osteosarcoma; leiomyoma and leiomyosarcoma; rhabdomyoma and rhabdomyosarcoma; epulis (gingival enlargement); angioma and angiosarcoma (tumours of blood and lymph vessels); round cell tumours; mesothelioma; epithelial tumours; squamous cell carcinoma,... and other contents.
172p muasambanhan04 11-01-2024 6 1 Download
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The main objective of this systematic review is to provide an overview of the discovery of novel associations of germline polymorphisms with treatment response and/or chemotherapy-induced toxicities in osteosarcoma.
21p vileonardodavinci 23-12-2023 3 2 Download
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The purpose of this study was to investigate the significance of preoperative C-reactive proteinto-albumin ratio (CAR), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in predicting overall survival (OS) of osteosarcoma, to establish a nomogram of an individualized prognostic prediction model for osteosarcoma.
9p vileonardodavinci 23-12-2023 4 2 Download
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Osteosarcoma (OS) mainly happens in children and youths. Surgery, radiotherapy and chemotherapy are the common therapies for osteosarcoma treatment but all their anti-tumor effects are limited.
12p vileonardodavinci 23-12-2023 5 4 Download
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Osteosarcoma (OS) is the most common primary malignancy of bone tumors. More and more ARHGAP family genes have been confrmed are to the occurrence, development, and invasion of tumors. However, its signifcance in osteosarcoma remains unclear. In this study, we aimed to identify the relationship between ARHGAP family genes and prognosis in patients with OS.
22p vileonardodavinci 23-12-2023 4 2 Download
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Osteosarcoma is the most common primary bone cancer that affects mostly children and young adults. Despite the advances in osteosarcoma treatment, the long-term survival rate of metastatic patients has not significantly improved in the past few decades, thus demonstrating the need for novel therapeutic targets or methods to improve metastatic osteosarcoma treatment.
16p vialfrednobel 23-12-2023 4 4 Download
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To investigate the potential role of Long Non-coding RNAs (lncRNAs) in the progression of osteosarcoma. Methods: The candidate lncRNAs were screened with RNA-seq and confirmed with quantitative real-time PCR. Using MTS, transwell assay, and fow cytometric analysis, the effects of overexpressed lnc-SELPLG-2:1 on cell functions were determined.
15p vialfrednobel 23-12-2023 8 3 Download
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The timing of events in the management of osteosarcoma may be critical for patient survivorship; however, the prognostic value of factors such as onset of symptoms or initiation of therapy in these patients has not been studied. This study sought to review the literature reporting treatment of osteosarcoma to determine the utility of event timing as a prognostic indicator.
8p vialfrednobel 23-12-2023 3 3 Download
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Osteosarcoma (OS) is one of the malignant bone tumors with strong aggressiveness and poor prognosis. Leucine-rich repeats and immunoglobulin-like domains2 (LRIG2) is closely associated with the poor prognosis of a variety of tumors, but the role of LRIG2 in osteosarcoma and the underlying molecular mechanism remains unclear.
10p vialfrednobel 23-12-2023 6 3 Download
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This research aimed to investigate the roles of fanconi anemia complementation group D2 (FANCD2) on the regulation of ferroptosis in osteosarcoma progression. The function of FANCD2 on cell viability, invasion, migration, and tumor growth were explored. FANCD2 and pathway-related genes were determined by western blot. Ferroptosis-associated markers were determined, including lipid peroxidation, labile iron pool (LIP), ferrous iron (Fe2+), and ferroptosis-related genes.
11p vischultz 20-10-2023 4 1 Download
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This study aimed to get a deeper insight into new osteosarcoma (OS) signature based on bone morphogenetic proteins (BMPs)-related genes and to confirm the prognostic pattern to speculate on the overall survival among OS patients.
14p vischultz 20-10-2023 1 1 Download
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Osteosarcoma is a malignant tumor that usually occurs in adolescents aged 10–20 years and is associated with poor prognosis. Ferroptosis is an iron-dependent cell death mechanism that plays a vital role in cancer.
18p vischultz 20-10-2023 2 1 Download