Optimization and physicochemical characterization of polymeric nanoparticles containing tinidazole

Periodontitis is a chronic bacterial infection destroying tooth-supporting tissues. Like metronidazole, tinidazole (TNZ) is also effective in treating periodontitis. The preparation of polymeric nanoparticles containing TNZ helps to improve the solubility and increase the bioavailability of the drug. Objectives: This study aimed to formulate and optimize TNZ nanoparticles and evaluate their physicochemical properties.