Protein kinase C inhibitor Gö6976 but not Gö6983 induces the reversion of E- to Ncadherin switch and metastatic phenotype in melanoma: Identification of the role of protein kinase D1

Melanoma is a highly metastatic type of cancer that is resistant to all standard anticancer therapies and thus has a poor prognosis. Therefore, metastatic melanoma represents a significant clinical problem and requires novel and effective targeted therapies.