Protein kinase C

The aim of this study was to investigate the interrelationships among PKC isoforms, telomerase and AFP in HCC. PKCα and PKCδ were the most expressed isoforms in HepG2/C3A, PLC/PRF/5, SNU-387 and SKOV-3 cells.

17p vikissinger 21-12-2023 1 1   Download

The protein kinase C (PKC) family of serine/threonine kinases contains more than ten isozymes that are involved in multiple signaling pathways, including cell cycle regulation and carcinogenesis.

7p vischultz 20-10-2023 3 1   Download

Nghiên cứu sự thay đổi C reactive protein (CRP) và creatine kinase (CK) giúp phát hiện và điều trị kịp thời nhiễm trùng sớm ở những bệnh nhân sau phẫu thuật xâm lấn tối thiểu, nẹp vít qua da và hàn xương liên thân đốt cột sống thắt lưng.

7p vischultz 17-10-2023 6 3   Download

Protein Kinase C-epsilon (PKCε) is a member of the novel subfamily of PKCs (nPKCs) that plays a role in cancer development. Studies have revealed that its elevated expression levels are associated with cervical cancer.

15p vioracle 29-09-2023 4 2   Download

Bài viết Đánh giá khả năng ức chế Protein kinase C của một số dẫn chất benzofuro[3,2-d]pyrimidin đánh giá hoạt tính ức chế CaPkc1 của ba dẫn xuất benzofuro[3,2-d]pyrimidine tổng hợp ở ba nồng độ khác nhau tương ứng 50 µM, 100 µM và 150 µM. Ở nồng độ 100 μM là tối ưu cho hoạt tính ức chế CaPkc1 với cả ba dẫn xuất benzofuro[3,2-d]pyrimidine tổng hợp.

9p viberbers 09-08-2023 9 2   Download

Hereditary spinocerebellar ataxias are a group of genetic neurological disorders that result in degeneration of the cerebellum and brainstem, leading to difficulty in controlling balance and muscle coordination.

6p vidoctorstrange 06-05-2023 2 2   Download

Protein kinase C (PKC) is a multifunctional serine and PKC can phosphorylate serine residues in the cytoplasmic domain of tyrosinase, thereby regulating the activity of tyrosinase. Activated PKC is bound to the melanosome membrane, and unactivated PKC is free in the cytoplasm of melanocytes.

10p vihagrid 30-01-2023 6 3   Download

Midostaurin combined with chemotherapy is currently used to treat newly diagnosed acute myeloid leukemia (AML) patients with FMS-like tyrosine kinase 3 (FLT3)-mutations. However, midostaurin acts as an antagonist to some chemotherapeutic agents in leukemia cell lines without FLT3 mutations.

14p vikolindagrabar 27-07-2022 4 2   Download

Anesthetic preconditioning can improve survival of cardiac progenitor cells exposed to oxidative stress. We investigated the role of protein kinase C and isoform protein kinase C-ε in isoflurane-induced preconditioning of cardiac progenitor cells exposed to oxidative stress.

7p viisaacnewton 25-04-2022 10 2   Download

Morphine-induced hyperalgesia and tolerance significantly limits its clinical use in relieving acute and chronic pain. Melatonin, a pineal gland neurohormone, has been shown to participate in certain neuropsychopharmacological actions.

8p viisaacnewton 26-04-2022 4 1   Download

Cancer stem cells (CSCs) are implicated in carcinogenesis, cancer progression, and recurrence. Several biomarkers have been described for pancreatic ductal adenocarcinoma (PDAC) CSCs; however, their function and mechanism remain unclear.

19p vimahuateng 26-11-2021 8 1   Download

Protein kinase C epsilon (PKCε) belongs to the novel PKC subfamily, which consists of diacylglycerol dependent- and calcium independent-PKCs. Previous studies have shown that PKCε is important in different contexts, such as wound healing or cancer.

8p vimariana2711 22-12-2020 9 1   Download

Balanol is an ATP mimic that inhibits protein kinase C (PKC) isozymes and cAMP-dependent protein kinase (PKA) with limited selectivity. While PKA is a tumour promoter, PKC isozymes act as tumour promoters or suppressors, depending on the cancer type. In particular, PKCε is frequently implicated in cancer promotion, making it a potential target for anticancer drugs.

12p viconnecticut2711 29-10-2020 13 2   Download

The serine-threonine kinase AKT1 plays essential roles during normal mammary gland development as well as the initiation and progression of breast cancer. AKT1 is generally considered a ubiquitously expressed gene, and its persistent activation is transcriptionally controlled by regulatory elements characteristic of housekeeping gene promoters.

12p virose2711 25-09-2020 17 1   Download

A subpopulation of tumor cells with distinct stem-like properties (cancer stem-like cells, CSCs) may be responsible for tumor initiation, invasive growth, and possibly dissemination to distant organ sites.

15p virose2711 25-09-2020 17 1   Download

We previously demonstrated that 6-benzylthioinosine (6-BT) could induce the differentiation of a subset of acute myeloid leukemia (AML) cell lines and primary AML cells regardless of their cytogenetics. In this study we investigated whether Wnt signaling pathways played roles in 6-BT-induced differentiation of AML cells.

10p vilisa271 22-09-2020 10 1   Download

Mitogen- and Stress-Activated Kinase 1 (MSK1) is a nuclear kinase that serves as active link between extracellular signals and the primary response of gene expression. However, the involvement of MSK1 in malignant transformation and cancer development is not well understood.

13p vialabama2711 21-09-2020 8 1   Download

Intrinsic and acquired resistance to drug therapies remains a challenge for malignant melanoma patients. Intratumoral heterogeneities within the tumor microenvironment contribute additional complexity to the determinants of drug efficacy and acquired resistance.

15p vinaypyidaw2711 26-08-2020 14 2   Download

Melanoma is a highly metastatic type of cancer that is resistant to all standard anticancer therapies and thus has a poor prognosis. Therefore, metastatic melanoma represents a significant clinical problem and requires novel and effective targeted therapies.

22p vimale2711 25-08-2020 9 2   Download

Bevacizumab combined with chemotherapy produces clinical durable response in 25–30% of recurrent glioblastoma patients. This group of patients has shown improved survival and quality of life. The aim of this study was to investigate changes in gene expression associated with response and resistance to bevacizumab combination therapy.

10p vimale2711 21-08-2020 12 1   Download