Quantification of verapamil hydrochloride in gastric floating tablets by high performance liquid chromatography

To establish and validate the methods to assay verapamil hydrochloride (VH) in gastric floating tablets by high performance liquid chromatography (HPLC). Materials and methods: The method was developed according to the monograph of VH extended-release tablets in the USP 43; the method was validated based on the ICH guidelines, including System suitability, selectivity, linear range, repeatability, accuracy, the limit of detection (LOD), the limit of quantification (LOQ).