Role of PAX8 in the regulation of MET and RON receptor tyrosine kinases in non-small cell lung cancer
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Non-small cell lung cancers (NSCLC) are highly heterogeneous at the molecular level and comprise 75% of all lung tumors. We have previously shown that the receptor tyrosine kinase (RTK) MET frequently suffers gain-of-function mutations that significantly promote lung tumorigenesis.
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