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Solid-phase total synthesis of cyclic peptide brachystemin A and its immunomodulating activity
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Brachystemin A (1) is a biologically active peptide from a Chinese traditional plant Brachystemma calycinum D. Don. (Caryophyllaceae). The current study describes the complete solid-phase total synthesis of peptide 1 by using Kenner’s sulfonamide safety-catch linker strategy. It was identified by QTOF/MS data and NMR studies. Synthetic peptide 1 was tested for its immunomodulatory effect on different inflammatory parameters, including production of inflammatory cytokines, interleukin 2 (IL-2), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β), and generation of nitric oxide (NO.).
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