TetR-family transcription factors in Gramnegative bacteria: Conservation, variation and implications for efflux-mediated antimicrobial resistance

TetR-family transcriptional regulators (TFTRs) are DNA binding factors that regulate gene expression in bacteria. Well-studied TFTRs, such as AcrR, which regulates efflux pump expression, are usually encoded alongside target operons. Recently, it has emerged that there are many TFTRs which act as global multi-target regulators.