Tổng kết các báo cáo liên quan đến phản vệ trong cơ sở dữ liệu báo cáo tự nguyện Việt Nam giai đoạn 2010-2019

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Nghiên cứu tiến hành nhằm tổng kết thông tin về các phản ứng phản vệ được ghi nhận từ các báo cáo tự nguyện trong cơ sở dữ liệu cảnh giác dược tại Việt Nam từ năm 2010-2019.

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Nội dung Text: Tổng kết các báo cáo liên quan đến phản vệ trong cơ sở dữ liệu báo cáo tự nguyện Việt Nam giai đoạn 2010-2019

Trung tâm DI&ADR Quốc gia - Tài liệu chia sẻ tại CANHGIACDUOC.ORG.VN và facebook CANHGIACDUOC AI . :. LEKETNAP. . THANG 11 .. SO 2 2020 A A A TONG HQI Y HOC VI~T NAM VIETNAM MEDICAL ASSOCIATION 68A Ba Tri~u - Hoan Kie'm - Ha NQi;Tel: 024-39431866 Email: tapchiyhocvietnam@gmail.com; Webslte: tonghoiyhoc.vn
. _ .. - - ------------ MUCLUC • • T~p CHi Y HQC VII;T NAM T~P 496 - THANG 11 - so 2 - 2020 VIETNAM MEDICAL JOURNAL N02- NOVEMBER - 2020 1. .. anh gia vai tro nQisoi 6 bunq trong chan doan va dieu tr] vet thu'dng tanq rang 1 Evaluation the role of laparoscopic in diagnostic and treatment of holow viscus perforation wounds Nguy~n Hoang Linh, Huynh Kim Khang, Ng_uy~nDuc Vd, Duong Van Hai, Nguyen Cong Minh 2. Phl:lc hoi thanh cong rang ora sua sau va Ion bang chup Zirconia co san 5 Treatment anterior crown with pre-fabricated Zirconia Trung tâm DI&ADR Quốc gia - Tài liệu chia sẻ tại CANHGIACDUOC.ORG.VN và facebook CANHGIACDUOC Nguy~n Anh DU'O'ng,Vo Truong NhU'Ngoc, Ngo Van Toan 3. Thl/c tranq hoat dQng tiem phong benh dai t9i tinh Gia Lai, giai dean 2015 - 2019 8 Situation of rabies vaccination in Gia Lai province, 2015-2019 Nguy~n Van Chuyen, Nguy~n Van Khai, Nguy~n Th] Minh Ngoc 4. B~c diem lam sang va ket qua dieu tr! nQisoi cam rnau mOi bang dong di~n 13 l:linical characteristicsand endoscopicelectrocauterytreatment outcomesof epistaxis Ha Phuong Thao, Trin Thi Mai 5. Nghien cuu bao che vien nen Fexofenadin hydroclorid phan tan nhanh de tang hi~u 16 qua dieu tr] vlem mOid! ung Preparation and evaluation of Fexofenadinehydrochloride rapid dispersible tablets to increasethe effectiveness for treatment of allergic rhinitis Vii Van Tu~n, Nguy~n Van B~ch 6. Nghien cuu cai thien dQon d!nh thudc tlern Rotundin sulfat de tang tac dl,mgan than 20 Study on improving stability of Rotundine sulfate injection to increase sedative effect Nguy~n Thi Ha, Nguy~n Van B~ch 7. Ket qua bu'ocdau nQisoi 0 bl:lngdieu tr! vet thu'dng cd hoanh 26 The initial result of laparoscopictreatment diaphragm wounds Nguy~n Hoang Linh, Huynh Kim Khang, Nguy~n Du-cVii, DU'ongVan Hai, Nguy~n Cong Minh 8. Nghien cuu d~c diem lam sang va c~n lam sang cua b~nh nhan viem gan B m9n tfnh 31 du'Q'cdi'eutr! bang thuac Tenofovir l:linical characteristics of chronic hepatitis B cured by Tenofovir Da Thi Quynh, Vii Van Nga, Bid Thi Thu Hoai a 9. Banh gia rai lo~n chuyen hoa cald - phospho - PTH b~nh nhan 19Cmau chu ky t9i 35 Khoath~n Tiet ni~u - L9Cmau, B~nh vi~n Huu Nghi Evaluating the metabolism trouble in dialysis patients at neuphrourology - dialysis department, Huu Nghi Hopital . Trinh Thi Thanh H~ng, Nguy~n Van Tin, Nguy~n Th~ Anh 10. Khao sat sl/ tuan thu dieu tri Tenofovir tren b~nh nhan viem gan B m~n tfnh 39 Investigation of Tenofovir treatment adherence in chronJchepatitis B patients Vii Van Nga, Do Thj Quynh, Vii Thj ThO'm, Le Thj Di~m HAng, Bui Thj Thu Hoai 11. O'ng dl:lng ky thu~t multiplex PCRphat hi~n cac gen mcr-1, mcr-2 va mcr-5 khang 43 a colistin cac chung Escherichiacoli phan I~p tu cac trang tr9i ga Ha Nam a Application of the multiplex PCRtechnology for detection of colistin resistant mcr-1, mcr-2 and mcr-5 genes in the Escherichiacoli strains isolated from the chicken farms in Ha Nam Hoang Thi }\1aiHU'O'ng,Hoang Thj An Ha, Vii Nhi Ha, Hoang Thj L~an, Phung The Khang, Ph~m Duy Thai, Trin Huy Hoang a 12. Banh qia tlnh tranq nhiem virus viem qan B, C b~nh nhan 19Cmau chu ky t9i khoa 48 Th~n tiet ni~u-19Cmau, B~nh vi~n Huu Nghi Infection with hepatitis Band C virus in dinalysis patients at the nephrology-dialysis department, Huu Nqhi Hospital , Nguy~n Van Tin, Trinh • Thi• Thanh x Han!!. Hoan!! Manh X Tron!!. I.. Nguyen Le Hoa, Nguyen The Anh
- - - - - --------_ 13. Thl/c tranq kern khoanq hoa men rang ham Ion - rang ctra 0 nhorn h9Csinh 12-15 51 tuoi t~i tinh Binh Dlnh narn 2019-2020 The current situation of molar incisor hypomineralistaton in group of 12-15 years old students in Binh Dinh province in 2019-2020 _ Nguy~n Phuc Minh, Vo Truong NhU'NgQc 14. Mqt so d~c diem dkh te hoc cac ca tu vong do benh dai tai tinh Sdn La (2015 - 2019) 55 Some epidemiologicalcharacteristicsof human rabiesin Son La province (2015 - 2019) Nguy~n Van Chuyen, Nguy~n Van Ba, Hoang Th] Thuan 15. Thay dOi tham my m~t nha voi ph§u thuat phoi hop dich chuyen tien ham va tao 59 hlnh cam Trung tâm DI&ADR Quốc gia - Tài liệu chia sẻ tại CANHGIACDUOC.ORG.VN và facebook CANHGIACDUOC Simulataneuos premaxilla osteotomy and genioplasty on the facial profile attractiveness of patients with convex face DB TuinNgoc, But Huu Phurrc, ve Hang Lie~, Hoang Tuin Anh 16. So sanh ke't qua dieu tr] dom nau anh sang cua Laser nano giay Q-Switched Nd: YAG 63 532 nm va Laser pico giay nd: YAG532 nm Q-Switched double frequency Nd:YAG 532-nm nanosecond Laser vs. double frequency Nd:YAG532-nm picosecond laser for the treatment of solar lentigines Pham Thj Mai Trinh, Le Hfru Doanh, ve Thai Ha 17. B~c diem di can h~ch bach huvet vung co trong ung thu bieu ma tuyen giap bi~t hoa 68 Characteristics of cervical lymph node metastasisin differentiated thyroid cancer Nguy~n Van Nam, TrAn Xuan BQ Vii Anh Hai, Le Thi Tuy~t Nhung 18. Mqt so d~c diem lam sang va c~n lam sang cua rang ham seraham tren co b~nh 1'1 71 tuy ho~i tU 0 mqt nhom b~nh nhan den kham t~i B~nh vi~n Rang Ham M~t Trung L(dng Ha Nqi nam 2019 Clinical and radiographic evaluation of primary upper molars with necrotic pulp of young patients at Hanoi National Hospital of odonto-stomatology Le NgQcDi~p, VOTruong Nhu NgQc, Ph~m Hoang Tuin, Nguy~n Thi Van Anh 19. Mqt so d~c diem dich t~ h9Cvi khuan Rickettsia 0 Mien sac Vi~t Nam 75 Epidemiological characteristics of Rickettsia in North Vietnam LuO'ngThi HAng Nhung, Nguy~n Vii Trung, Le Thi HQi, Ma Thi Huyin 20. Thl/c tr~ng tai n~n thL(dng tfch cua tre nh~p khoa cap cuu t~i B~nh vi~n Nhi Trung 79 L(dngtU' 7/2019 - 6/2020 Situation of children's injury admitted the emergency department at viet nam National Children's Hospital from 7/2019 - 6/2020 Nguy~n Thi Huyin Sam, Truong Thi Mai HAng 21. Banh gia ket qua ph§u thu~t dieu tri h~p dqng m~ch canh ngoai S9 t~i B~nh vi~n Da 82 khoa Dong Nai Results of extracranial carotid artery endarterectomy in Dong Nai Province Hospital Tr~n Quy~t Ti~n, Nguy~n Anh Diing 22. Hi~u qua rna hinh phl:1Choi chuc nang dl/a vao cQngdong cho ngL(Oikhuyet t~t v~n 86 dQngt~i huy~n Thong Nhat tinh Dong Nai The effectiveness of community-based rehabilitation for people with mobility disabilities in thong nhat district Dong Nai Province Nguy~n HAng Quang, Nguy~n Xuan Bai, Ph~m Van TrQng 23. Ket qua ph§u thu~t nQisoi cat rUQtthLtaqua dL(ongam d~o 90 The results of laparoscopic appendectomy through vaginal route DB Tit Thanh, Tr~n Binh Giang
24. Kha nang cung ung dich vu cham soc tre so sinh tal Trung tam Y te huyen Kim Boi, 93 tinh Hoa Binh, narn 2019 Infant care service delivery providing at Kim Boi District health center in Hoa Binh Province in 2019 Nguy~n QuAc Ti~n, Nguy~n Quang T,!, Nguy~n Dang Vtmg, Pham Hai Thanh, Nguy~n Huu Thing 25. Cck yeu to dlj bao ket cue d benh nhan dQt quy thleu rnau nao cec bQ cap tfnh du''c 97 dieu tr] tai tu'oi mau bang lay huyet khoi cd hoc ket hop d~t stent cap ciru thuoc tuan hoan nao truce Outcome forecast factors in patient with acute ischemic stroke received reperfusin Trung tâm DI&ADR Quốc gia - Tài liệu chia sẻ tại CANHGIACDUOC.ORG.VN và facebook CANHGIACDUOC treatment using mechanical thromboembolism combined with anterior cerebral circulation emergency stent Nguy~n Van Huy, Mai Duy Ton, Le HAng Trung Dito Vi~t Phuong, Vii Dang LU'U,Tdn Anh Tu~n 26. Tinh hinh tang ap luc 0 bunq va mQt yeu to nguy co 0 benh nhan n~ng nh~p vi~n 102 khoa Hoi sire Tfch cue Intra-abdominal hypertension and some risk factors in patients who admitted to the intensive care unit D~ng Th] Huong, Dao Xuan CO' 27. Hoi tu'dng quan giG'a ap luc nQi SQva diem glassgow d b~nh nhan xuat huyet nao 5 105 ngay dau Correlation between the intrcranial pressure and glassgow score in patients with brain hemorrhage for the first 5 days Le Thi Bich Thiiy, ~guy~n Van ChU'O'llg 28. KhilO sat cac yeu to lien quan den muc dQ n~ng cua b~nh gan nhiem ma khong do ru''u 109 Related factors of severe nonalcoholic fatty liver disease Vo Duy Thong, D6 Duc Minh 29. Tinh tr~mg trCing qua huyet ap Iu'u dQng d b~nh nhan IQcth~n 113 Dipper pattern on ambulatory blood pressure monitoring in the hemolysis patients Chau Huu HAu, Nguy~n Minh Tri 30. KhilO sat ta du'Q'cdong kho cho cong thl)'C bao che thuoc tiem dong kho liposome 117 amphotericin B Investigation lyophilized excipients for the preparation formulation of liposomal amphotericin B for lyophilized injection Nguy~n Tu~n Quang, Ph~m Thi Minh Hu~, Nguy~n Thai SO'll 31. HQt so yeu to lien quan toi thai gian dieu trl cua ngu'ai b~nh viem loet giac mi;lc 120 Factors related to treatment duration in patients with corneal ulcer D~ng Thi Hai Hit, Ph~m HAng Van 32. Banh gia hi~u qua kiem soat ho hap cua phu'dng phap thong khf ap Iljc du'dng ngat 123 quang dau trung tam ket h'pngoi;li vi trong ph§u thu~t ti;lo hinh khf quan Evaluate the effectiveness of airway management using distal tracheal intubation and intermittent positive pressure ventilation for tracheal resection and reconstruction surgery Dinh Thi Thu Trang, Nguy~n Minh Ly, Cong Quy~t Thing, TAng Xuan Hung 33. Thljc tri;lng dam bao thuoc thong qua hinh thuc dau thau ti;li B~nh vi~n Quan Y 105 128 tlt nam 2015 - 2018 Current situation of drug security through drug bidding at 105th military hospital from 2015 to 2018 HACanhH~u, Nguy~n Minh Chinh, Hoang Hai, Nguy~n CAm Van, Vii NgQcMai
34. Nghien cuu d~c diem lal}l sang due the thuv tinh sau chan thu'dng va mQt so yeu to 132 tien hrono thi nrc sau ohau thuat dieu tri Clinical characteristics and prognostic factors for visual outcome of traumatic cataract Pham Phuong Dung, Th§m Truong Khanh Van 35. 8anh gia ket qua phuc hoi chuc nang nh~n tmrc cho benh nhan chan thu'dng S9 nao 136 tal B~nhvi~n Phuc hoi Chuc nang Ha NQinarn 2019 - 2020 Functional cognitive assessmentof the patient after traumatic brain injury Phan Thi Ki~u Loan, Ph~m Van Minh 36. Banh gia hi~u qua phuc hoi chirc nang thang bang tren ngu'oi benh nhoi rnau nao t1;li 139 B~nhvi~n Lao khoa Trung u'dng Assessment the effectiveness of balance rehabilitation for patients after cerebral Trung tâm DI&ADR Quốc gia - Tài liệu chia sẻ tại CANHGIACDUOC.ORG.VN và facebook CANHGIACDUOC infarction at National Geriatric Hospital aa Thi HUiYDgMinh, Cao Minh Chau 37. B~c diem lam sang va c~n lam sang cua benh nhan tnrot dot song don tang do 142 khuyet eo Clinical and subclinical of patients with one-level lumbar spondylolisthesis . Tdn HBng Vinh, Nguy~n Van Thach, Vii Van Hoe 38. Khao sat chi so FIB-4 trong dl,( doan gian tinh mach thirc quan d b~nh nhan xd gan 145 co chu'ang Investigation apri indicator to predict esophageal varices in cirrhosis patients with ascites ve Duy Thong, HAThi Van Anh 39. Thl/c tranq ngu'oi khuyet t~t v~n dQng va phuc hoi chirc nang cho ngu'oi khuyet t~t 149 v~n dQngdl/a vao cQngdong tc;lihuy~n Thong Nhat tinh Dong Nai The current situation and community-based rehabilitation for people with mobility disabilities in Thong Nhat district Dong Nai Province Nguy~n HAng Quang, Nguy~n Xuan Bai, Ph~m Van TrQng 40. Danh gia chat 1u'Q'ngkhOitieu (au trong quatrlnh baoquanva moi lien quan giO'acu'ong 153 dQhuynh quang vai doi song cua tieu cau du'Q'csan xua'tbang phu'dngphap buffy coat Assessment the quality of platelets during storage period and the colleration between the fluorescence intesity and the lifetime of platelets produced by buffy coat method Nguy~n Thj Lan, Luu Thj Thu Phuong,Tr§n Van Tinh, . Nguyin Dac Thao, Tr§n Thj Thanh Tam 41. Nhu cau cham soc dai hc;lncua ngu'oi cao tuoi d mQt so xa thuQc huy~n Soc Sdn, Ha 157 NQinam 2018 - 2019 .tong-term care need of elders in some wards in SocSon district, Ha Noi in 2018 - 2019 Nguyin Thi Thu Huy~n, Ph~m Le Tuin 42. Phau thu~t ung thu'tuyen giap d ngu'Oib~nh Basedowtc;IiB~nhvi~n NQitiet Trung u'dng 160 Thyroid cancer surgery in patients with Basedowdisease at the National Hospital of endocrinology " Ph~m Quyet Thang,' Tran, NgQc Luong Da Thanh Cong, Truong Quang Huy 43. Banh gia cau truc vi the va dQ ben cua ma van tim lQ'nsau bao quan Ic;lnhsau 164 Evaluation of the microstructure and tensile strength of the cryopreserved porcine heart valve Cu Thj Bich Thuy, Ngo Duy Thin, Duong Cong Nguyen, Le Thj HAng Nhung, M§u Van Cal!h 44. Kinh nghi~m bu'ac dau sU'dl,lng du'ong lIlo it xam Ian qua md ngl/c phai trong ph§u 168 thu~t thay van hai 113 tc;liB~nh vi~n ChQ'Ray Early experience of minimal invasive surgery by the right thoracotomy in mitral valve replacement at the cardiac surgery deparment of Cho Ray Hospital . Lam Tri~u Phat, TrAn Quy~t Ti~n
45. U'ng dunq thuc nqhlern phau thuat n9i soi qua duang am dao tren lon giai doan 173 2011- 2014 Applying experimental laparoscopic appendectomy throu~h vaginal route on pig D6 Tat Thanh, Trin Blnh Giang 46. Kha nang cung lIng dich vu cham soc SlICkhoe so sinh tal cac Tram Y te xa, huy~n 176 Kim BOi,tinh Hoa Blnh, nam 2019 Ability to provide neonatal medical health care services at commune healthcare stations at Kim Boi Provine, Hoa Binh District, 2019 Nguy~n Qu6c Ti~n, Nguy~n Quang Tu, Nguy~n Dang Vu'ng, Pham Hai Thanh, Nguy~n Hfru Thi~g 47. Banh gia ket qua phau thuat cat amidan bang dao Ligasure 179 Trung tâm DI&ADR Quốc gia - Tài liệu chia sẻ tại CANHGIACDUOC.ORG.VN và facebook CANHGIACDUOC The evaluation results of tonsillectomy method with Ligasure Nguy~n Phuong Thao, Nguy~n Quang Trung 48. Nghil~nClIUsir thay doi the tfch the chai tren hinh anh c9n9 hu'ang tir a benh nhan 182 nghi~n ruou Research on change in volumes of corpus callosum on magnetic resonance imaging of the alcoholic patient Le Phi Dlili, Nguyen Thi Sinh, Tran Ngoc Anh, D~ng Ti~n Truong 49. B~c diem lam sang, chan doan hinh anh b~nh Iy do d!ch nao tuy do vo nen S9 sau 185 chan thu'dng S9nao t~i B~nh vi~n Vi~t £)lIC «;Iinical characteristics and imaging evaluation of cerebrospinal liquid leak (csf) caused by skull base fracture post traumatic injury in Viet Duc Hospital . _ Ngo Manh Hung, TrAn Blnh Ngoc, Nguyjn Duc Dong 50. Banh gia tinh tranq nhiem khuan b~nh vi~n a b~nh nhan du'qc dieu tr! ECMOt~i 188 B~nhvi~n B~ch Mai Evaluate hospital associated infections in patients who were on ECMOat Bach Mai Hospital Trin Duc Trung, Dao Xuan CO' 5!. C.c3c yeu to anh huang ket qua dieu tr! viem loet d~ day ta trang helicobacter pylori 193 du'dng tfnh bang phac do 3 thuoc Amoxicilin, Levofloxancin, PPI t~i B~nh vi~n Trung U:dnaThai Nauven Clinical factors influencing the efficacy of H.pylori eradication of triple therpy (Amoxicilin, Levofloxancin, PPI) in Thai Nguyen General Hospital Ngo Duc hQ'P, Duong HAng Thai, Nguy~n Thj Thu Huy~n 52. Tinh hinh nhi~m nam Malasseziatren benh nhan viem da cd dia tai Benh vien Da 197 Ii~u Trung u'dng . . .. . Malassezla infection in patient with atopic dermatitis at National Hospital dermatology and venerology Nguy~n Van Hi~u, Trin CAm Van, Phlilm 'fhi Minh Phuong 53. Banh gia ket qua hoax~ tri dong thai tjen phauungthu' bieurna thl/c quan 1/3 giO'adu'Oi 201 Assessment of the rusults of preoperative chemoradiotherapy for esophageal cancer Phlilm Quang Anh, VO Van Xuan 54. Banh gia d9C tfnh ban tru'ang di ~n tren h~ t~o huyet cua vien nang ClIng Fucolen 205 sau bao che tren d9n9 v~t thl/c nghi~m Examines the semi-chronic toxicities of Fucolenon experimental animals Trin Thanh Huong, TrAn Van Thuin, Vii Mlilnh TuAn, Nguy@n Van Khiem, Dao Van Tu, Nguy~n Ti~n Quang 55. Nh~n xet ket qua sau 2 tuan dieu tr! Esomeprazoletrong viem diil day khang kern 210 theo loet a tre nhi~m Helicobacter Pylori tiili B~nhvi~n Nhi Trung u'dng Assesment of treatment result with esomeprazole after 2 weeks for non- ulcer gastritiS combined Helicobacter Pylori infection in vietnam national Hospital'SChildr~n DilO Thj Ngoan, Phan Thj Hien
56. B~c diem lam sang c~n lam sang va thai gian song them khang benh ung thir bieu 214 ma tuyen che nhay de day giai doan II, III Clinical characteristics and complementary examination, disease free survival and some factor affect disease survival of mucious gastric cancer stage II-III Nguy~n Thi H~ng, Trinh Le Huy, Le Van Thimh 57. B~c diem lam sang va m9t so yeu to lien quan den b~nh vlem da dau tal B~nh vi~n 218 Da Ii~u Trung u'dng Clinical manifestations and several factors relating to seborrheic dermatitis in National Hospital of Dermatology and Venereology Truong Th] Thanh Huong, Nguy~n Huu Sau, Trin cim Van Trung tâm DI&ADR Quốc gia - Tài liệu chia sẻ tại CANHGIACDUOC.ORG.VN và facebook CANHGIACDUOC 58. B~c diem lam sang va nhu cau cham soc dieu du'ong trong ngay dau cua ngu'ai benh 221 c6 h9i chung cai nrou Clinical characteristics and needs for care in the first day of of patients with alcohol withdrawal syndrome DB Thi Hoa, Nguy~n Doan Phuong, Le Thi Thu Ha, Nguy~n Th] Hila, Pham Xuan Thing 59. Ket qua sam ph§u thuat teo ruot non bam sinh tal B~nh vi~n HO'unqhl Vi~t Duc giai 225 doan 2017 - 2019 Results of surgical treatment for jejunoileal atresia in infant at Viet Duc University Hospital from 2017 to 2019 Chu Minh Phuc, Nguy~n Vi~t Hoa, Vii Hang Tuan 60. Bi~u qua dieu tri cua colchcin trong may day man tfnh til phat 229 Colchicine in the treatment vietnamese patient with chronic spontaneous urticaria Ngo Th] Minh Nguy~t, Pham Thj Lan 61. Banh gia ket qua dieu tr] Erlotinib bu'ac m9t tren benh nhan ung thu' phoi khang te 233 bim nho giai dOe;!niv c6 d9t bien EGFR Assessment treatment outcome of first-line Erlotinib in patients with advanced EGFR mutation-positive non-small-cell lung cancer Nghiem TrAn VU'Q'Ilg,Nguy~n Ti~n Quang, Le Thi Y~n 62. Trai nghi~m cua giang vien ve chu'dngtrlnh giao dl,lcdieu du'ong dy'a vao nang h!c 237 Perceived experiences of nurse educators in a competency - ba.sed nursing curriculum: a qualitative descriptive study Nguy~n Thi HAng Anh, Ph~m Thi Thuy Dung 63. Thl/c tre;!ngtiem chung day du va dung lich cua tre em du'ai 1 tuoi t9i huy~n Tr9m 241 Tau, tinh Yen Bai nam 2019 The fully and scheduled immunized situation among under 1-year-old children in Tram Tau district, Yen Bai province in 2019 Cao Bach, LQCThi Mai, Le Thi Thanh Xuan 64. Ket qua dieu tri soi ni~u quan 1/3 du'ai bangTamsulosinti;li B~nhvi~n De;!ihQcY Ha N9i 245 Results of therapy of therapy of under 1/3 by Tamsulosin treatment in Hospital University of Hanoi Trinh Anh Tu§n, Vii Nguy~n Khai Ca 65. Gia tri cua tY I~ dau ra nang noan (FORT)vai ket qua kfch thfch buang trung 248 Use of follicular output rate (FORT)to predict ovarian stimulation outcome Ph,m Thi Anh, Nguy~n Lien PhU'ong, LU'UQuynh HU'ong, HA Sy Hung 66. Khao sat cau truc vi the thanh tinh machtinh cua nhO'nqbenh nhan qian tinh mi;lchtinh 252 Evaluating the microstructure of veinous walls in patients with varicocele Nguy~n Hoai Bic, Dinh Van Toan, Ph,m ThuAn M,nh, Hoang Long
67. Hi~u qua khU'te bao mang nqoel tim bo bang Sodium Dodecy Sulfate 256 Decellularized effect and extracellular structure of bovine pericardium after treatment with Sodium Dodecy Sulfate Nguy~n Van Hoang, Ngo Duy Thin, i.e Thi HAng Nhung, Miu Van Canh 68. "~c diem lam sang, nQisoi va mo benh hoc 0 benh nhan dieu tr] cat tach nlem mac 259 dai true trang Clinical, endoscopic and histopathological features in patients undergoing endoscopic submucosaldissection Le Phu Tai, Nguy~n Cdng Long Trung tâm DI&ADR Quốc gia - Tài liệu chia sẻ tại CANHGIACDUOC.ORG.VN và facebook CANHGIACDUOC 69. Khao sat tinh tri;!ngnhiemkhuantiet ni~u 0 benh nhantrong 3 thang aau saughepth~n 263 Investigationof the urinary tract infections in kidney transplant recipents in the first 3 months after transplantation in bach mai hospital Hoang Thi Nhan, Mai Thi Hiin, Nguy~n Thi Hmrng 70. Hi~u qua cua phu'dng thirc AVAPS0 benh nhan d
78. Khaa sat dQ dai co tU' cung 0 1000 thai phu c6 tuoi thai tir 20-24 tuan bang sieu am 298 qua du'ang am dao Evaluatian of the cervical length at 20-24 week' gestatian in 1000 pregnancies by transvaginal ultrasound H~ Van Quy, Vii Ba Quy~t, Nguy~n Xuan Hq'i, _ Dao Thi Hoa, Phan Thi Thu Nga 79. Ket qua dieu tr] naa LIng thuy bam sinh bang phau thuat nQi sot pha san naa that III 302 ket hop dot dam roi mach mac Outcames of treatment cangenital hydracephalus by endoscopic third ventriculastamy withcharoid plexus cauterizatian . Dao Th] Mo, Cao Vii Hung, 1)8 Thanh Huong Trung tâm DI&ADR Quốc gia - Tài liệu chia sẻ tại CANHGIACDUOC.ORG.VN và facebook CANHGIACDUOC 80. Banh gia ket qua dieu tr] ung thu' phoi khong te baa nh6 giai doan III tren ngu'ai caa 305 tuoi bang h6a X
TAP CHi Y HOC VIET NAM TAp 496 - THANG 11 - 56 2 - 2020 f>i;lihoc Y Ha NQi,Ha NQi, clinical trials: analysis of three large multicenter, 2. K. M. Matsuda et al., 2019, Skin thickness score double-blind, randomized controlled trials, Arthritis as a surrogate marker of organ involvements in and rheumatism, 60, 8, 2490-2498 systemic sclerosis: a retrospective observational 6. T. L. Moore, M. Lunt, B. McManus, M. E. study, Arthritis research & therapy, 21, 1, 129-129 Anderson, and A. L. Herrick, 2003, Seventeen- 3. 1. Varga, 2014, Overview of the clinical point dermal ultrasound scoring system-a reliable manifestations of systemic sclerosis (scleroderma) measure of skin thickness in patients with systemic in adults, UpToDate. Waltham, MA. Retrieved sclerosis, Rheumatolo~y (Oxford), 42, 12, 1559-63 August, 4, 2014 7. L. P. Lan, 2015, f>ac diem lam sang, can lam 4. V. Leroy et al., 2019, Association of skin s,~ngv~ c~u'cDang t~on~ kh.iyh~i (1 benh nhan xo hyperpigmentation disorders with digital ulcers in cl1ng bl h~ thong, LUi;lnan tien Sly hoc, f>ai hoc Y systemic sclerosis: Analysis of a cohort of 239 Ha NQi, . . . Trung tâm DI&ADR Quốc gia - Tài liệu chia sẻ tại CANHGIACDUOC.ORG.VN và facebook CANHGIACDUOC patients, J Am Acad Dermatol, 80, 2,478-484 8. N. S. Goh et al., 2008, Interstitial lung disease in 5. S. Amjadi et al., 2009, Course of the modified systemic sclerosis: a simple staging system, Am J Rodnan skin thickness score in systemic sclerosis RespirCrit Care Med, 177, 11, 1248-54 ,.." "., , , ,,.. TONG KET CAC BAO CAO LIEN QUAN DEN PHAN VE TRONG CO' ,..,? A' sa . BAo cAo TU'...NGUYEN VIET NAM GIAI DOAN ,nCr LIEU . 2010-2019 Truong Th] Mint, Nguy~n Phuong Thuy\ Nguy~n Hoang Anh2, D~ng Bieh Vi~t2,Cao Thj Thu Huy~n2, Nguy~n Hoang Anh', , Vii Dlnh Hoa2, Nguy~n Van Dinh3 nhat de xU'tri phan v~. Ket qua nghien ciru cung cap T6MTAT. thong tin can thiet cho hoat dQng theo doi va xU' tri Nghien oru du'gc tien hanh nham tong ket thong phan v~ ti;li cac don vi dieu tri cung nhu' gqi y cho cac tin ve cac phan ung phan v~ du'gc ghi nh~n tlt cac bao giai phap can thi~p cua cac cac cd quan quan Iy doi cao tlj nguy~n trong cd so dO'Ii~u canh giac du'dc t~i voi bien cO'y khoa nghiem trQng nay. Vi~t Nam tlt nam 2010 den 2019. Cac bao cao tv' Til' khoa: phan ung phan v~, bao cao ADR, ti Ie nguy~n du'gc sang IQ.cdu cac thong tin yeu cau cho bao cao, xII tri phan v~, adrenalin. . qua trinh danh gia phim ung theo tieu chuan dinh tru'ck. f>~cdiem cua hOi;ltdQng bao cao, d~c diem cua SUMMARY thuoc nghi ngo va phim ung phim v~ du'gc ghi nh~n ANAPHYLACTIC REACTIONS IN cling voi t~o.ng tin ve xu tri ti;li ddn vi dieu tri du'gc SPONTANEOUS REPORTING DATABASE OF tong ket va mo ta. Ket qua cho thay phan v~ chiem 13,7% so bao cao tv' nguy~n ADR ti;li Vi~t Nam. f>dn vi VIETNAM FROM 2010 TO 2019 bao cao chu yeu thuQc khoi cong I~p (94,5%). Du'qc The current study analyses information of 59 la doi tu'gng bao cao phan v~ nhieu nhat (41,4%). anaphylatic reactions (AR) based on spontaneous Co 81,8% bao cao ghi nh~n thong tin khai thac tien sU' reports to National Pharmacovigilance Center from di ung trong do co 1,6% b~nh nhan co tien sU'di ((ng 2010 to 2019. Individual Case Safety Report (ICSR) voi thuoc nghi ngo va 2,0% b~nh nhan co tien su di were screened for essential information and the AR U'ngthuoc cling nhom vOi thuoc nghi n90. Khang sinh was assessed followed a prespecified criteria. The cephalosporinva carbapenem (51,5% tong so bao cao characteristic of reporting activity, suspected phan v~), khang sinh penicilin (9,5%), thuDc can medications and reported reactions were summarized and described. The reported AR were in 13,7% of quang (5,3°~o),N~,!\IDs t5,oo/~}la .~hO'n~nhom}h~§c du'gc bao cao nhlE:~u nhat. Cac tn~u chl1ng pho bien spontaneous ICSR in Vietnam. The public sector had nhat cua phan v~ la tren tuan hoan ~75,2%}, ho hap major contribution, accounting for 94.5%. Pharmacists (74,6%), da/niem mi;lc (55,6%). Co 38,4% tru'ong were most active reporters contributing to 41,4% of hgp co bieu hi~n hi;l huyet ap nghiem trQng, 67,9% ICSR.The history of allergy was reported in 81,8% of tru'ong hqp du'gc can bQy te danh gia la nghiem trQng cases. Of those, allergic to suspected medications or va co 1,6% tru'ong hgp t(t vong. Corticoid (72,7%) va allergiC to medications which might cross reactivity adrenalin (68,2%) la 2 thuDCdu'gc su dl,mg pho bien with the suspected one were 1,6%· and 2,0% respectively. The leading suspected medications were cephalosporins and carbapenems (51,5%), penicilin ) Tfllt7ng Cao Dang DI.I(fc 7W Hai Dl.ldng (9,5%), contrast media agents (5,3%) and NSAIDs 2Trung tam DI&ADR QG, Trl.lt7ng D~i h9C DI.I(fc Ha N9i (5,O%). The manifestations of RA occurred mainly in 3Mnh v$n Quifc te'Vinmec Times City, D9i t'9C VinUniversity cardiovascular, repiratory and subcutaneous systems Chiu trach nhi~m chinh: Tru'dng Thi Man with prevalence of 75,2%, 74,6% and 55,6%, Email: vudinhhoa@gmail.com respectively}. Severe hypotension was reported in Ngay nh~n bai: 24.9.2020 38,4% of cases. Servere reactions have been Ngay phan bi~n khoa hQc: 30.10.2020 identified by reporters in 67,9% of reports, and the Ngay duy~t bai: 11.11.2020 fatality rate was of 1,6%. Adrenalin and corticoid were 323
VIETNAM MEDICAL JOURNAL N°2 • NOVEMBER· 2020 used to manage AR in 72,7% and 68,2% of patients, Tieuchuanloai tnn Cac bao cao ADRthieu respectively), This study provides information for the thong tin ve thucc 'nghi ngo va bieu hi~n ADR. management of anaphylatic reactions in healthcare 2. Phu'dng phap nghh1!ncuu. Mo ta thong centers and suggests for the intervention of authority, Keywords: Anaphylactic reaction, ADR report, qua hoi cuu cac tru'ong hop phan v~ du'qc bao reportingproportion,anaphylaxismanagement,adrenalin cao ve Trung tam DI&,ADRQuoc gia trong giai doan 2010-2019 voi cac chi tieu: So IWng, tY I~ I. £>AT VAN £>E v '" '"' bao cao phan v~ trong cd so dG'Ii~u theo nam: Philn v~ la mQt phan ((ng di ((ng toan than, thong tin hanh chinh ghi nhan tu bao cao phan cap tinh xily ra sau khi tiep xuc voi di nguyen. Day du'qc coi la mQt trong nhG'ngphan ((ng nguy v~; D~c diem b~nh nhan ghi nhan bao cao tu phan v~; D~C diem cua thucc nghi ngo gay phan Trung tâm DI&ADR Quốc gia - Tài liệu chia sẻ tại CANHGIACDUOC.ORG.VN và facebook CANHGIACDUOC hiem nhat tren lam sang do thai gian khoi phat v~; D~c diem cua phan v~, cach xU' tri va ket nhanh, c6 the gay t(( vong va khong the dl/ doan qua sau xU'tri du'qc. Trong cac nguon dG' Ii~u ve philn v~, bao Nhom thuoc c~a cac hOc;ltchat nghi ngo gay cilO tl/ nguy~n ve philn ((ng co hc;licua thuoc phan v~ du'qc phan 10c;li dl/a tren cd so phan 10c;li (ADR) du'qc coi la n~uon thong tin quan trQng rna ATC). Thai gian tiem tang xuat hi~n philn v~, giup danh gia d~c diem cGng nhu' sl/ hinh thanh bieu hi~n cua philn 1~ tren cac h~ cd quan (phan tin hi~u philn v~. Ti;!i Vi~t Nam, theo nghien c((u 10i;!itheo Hu'ong dan WHO - ADR Terminology cua Le Thi Thuy Linh, so Iu'qng bao cao philn v~ 2012) [6], m((c dQ nghiem trQng cua cac tru'ong giai dOc;ln2010-2014 ta 2.161 ca, chiem 10,55% hdp philn v~ phan 10c;li theo Brown [3] va Hu'ong tong so bao cao ADR [2]. Trong giai dOc;ln2010- d§n QUocgia ve Cilnh giac Du'qc. 2016, Nguyen Khac DGng va cQng sl/ ghi nh~n 3. xU' Iy dU' Ii~u. Toan bQ dG' Ii~u du'qc 55 bao cao philn v~ gU1ve Trung tam DI&ADR nh~p, xU' 1'1'tren phan mem Microsoft Office QUocgia la 4.873 ca, chiem 13,2% tong so bao Excel 2016 va SPSS22.0. Cac bien du'qc thong cao ADR [4], trong do co 111 ca t(( vong (chiem ke theo tan suat va tY I~ phan tram. 82% so Iu'qng ca t(( vong trong 7 nam cua toan bQcd so dG'Ii~u ADR), trong khi do b~o cao lien III. KET QuA NGHIEN CU'U quan den philn v~ chi chiem 0,9% tong so bao Tu 73447 bao cao tl/ nguy~n Iu'utrG'ti;!i trung cao trong cd so dG' li~u bao cao ADR toan cau tam 01 & ADR Quoc gia giai dOc;ln2010-2019, cua To ch((c Y te the gioi (Vigilyze) [5], Xuat sau khi 10i;li1971 bao cao, co 10027 bao cao phat tu thl/c te tren, nghien c((u du'qc thl/c hi~n philn v~ da du'qc du'a vao nghien c((u. nham tong ket d~c diem bao cao lien quan den Sc) Iu'qng, tV I~ bao cao phim v~ thf!o nam philn ve trong cd so dG' li~u bao cao tl/ nguy~n 2500 20 Vi~t Na'm giai dOc;ln2010-2019 de h~ tr$1cong 18 tac bao cao, x(( tri, dl/ phang va giilm thieu nguy ,,po 2000 16 > co cua philn v~. c -III 14 11.001TlIQNG VA PHlfO'NG PHAp NGHIENc(J'u "E. 1500 12 'i 0 10 ..... -III 1. D61tu'dng nghien cuu. Tat cil cac bao u :!!' o 1000 8 cao tl/ nguy~j, ve philn ((ng co hc;licua thuoc -III .0 6 ?: (bao cao ADR) do can bQ y te tren phc;lmvi cil ~ 500 nu'oc gU1ve Trung tam DI&ADR QUoc gia giai doan 2010-2019. 0 0 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 'Du'a vao tieu chuan chan doan cac tru'ong ....... 56 bao ,ao ph"n v~ _ TV I~ vOl t6ng so baD cao nghlen c(I'U(%) hdp 'philn v~ du'qc quy dinh trong Thong tu' si/2017/TT-BYT [1], cac bao cao philn v~ du'qc Hinh 1:So'lutlng va tY I~ bao caophan v~ du'a vao nghien c((u neu thea man 1 trong 2 theo tung nam dieu ki~n sau: So Iu'qng bao cao philO v~ tang aan qua cac - £)u'qc can bQy te me til la soc philn v~ ho~c nam tlt 155 bao cao (nam 2010) len 2235 bao philO ((ng philn v~ cao nam 2019 (hinh 1). T'1 I~ bao cao philn v~ - ADRxuat hi~n trong yang 1 ngay tinh,tu Ian tren tong 55 bao cao ADR cua tung nam dao dung thu5c cu5i cung va co it nhat mQt bieu hi~n dQng trong khoilng 9,1%-17,3% quanh gia tri tren 2 trong 4 h~ cd quan da/niem mc;lc-hohap- trung binh la 13,7% tieu hoa-tim mc;lchho~c co bieu hi~n hi;!huyet ap D~c diem cua ho~t dQng bao cao. Ddn vi nghiem trQng. bao cao chu yeu thuQc khoi cong I~p (94,5%) 324
TAP CHi Y HOC VIET NAM TAp 496 - THANG 11 - s6 2 - 2020 trong do benh vi~n tuyen tinh/thanh pho la don Khong co thong tin I 68 I 0,7 I v] tham gia bao cao nhleu nhat (chiem 44,8%), Cac bao cao phan v~ duoc glri den Trunq tam khoi benh vlen tu' nhan chi chiem 5,5%. Ducc s9 trong vonq 1 tuan chiem 26,2%, tu 1 tuan - 1 va bac s9 la 2 doi W
VIETNAM MEDICAL JOURNAL N°2 • NOVEMBER· 2020 4 Diclofenac 289 2,9 5 Cefuroxim 254 2,5 6 Iobitrldol 251 2,'5 7 Ciprofloxacin 247 2;5 8 Cefoperazon 241 2',4 9 Paracetamol 216 22 10 Cefoperazon/sulbactam 213 2,1 f)u'ong dung cua cac thuoe nghi ngo gay phan ve 1 Tinh mach 7850 78,3 2 Uong 1794 17,9 Trung tâm DI&ADR Quốc gia - Tài liệu chia sẻ tại CANHGIACDUOC.ORG.VN và facebook CANHGIACDUOC 3 Tiem bap 1011 10,1 4 Du'ong dung khac 686 6,84 - , , A .- N , , A , - Nhung du'ong dung pho bien nhat trong cac bao cao phan ve la du'ong tmh mach (78,3%), du'ong , uong (17,9%), du'ong tiem bap (10,1%). Cac du'ong dung khac (bao gam: gay te, tiem du'oi da, d~t h~u mon, khf dung, ng~m du'oi Iu'Oi,du'ong dQng mach, born vim tlt cung, thuy cham, nho mat, nho mUi) chiem 6,84%. f)ije diem ella phim v~ ghi nh~n trong bao cao. Da so cat baocao phanv~ co thai gian tiem tang du'oi 10 phut (49,2%), 32,5% phan ltng xay ra trong yang tU' 10 phut den 1 giO va chi co 7,7% cac tru'ong hcp xay ra sau 1 gia. Co 10,6% bao cao khong ghi r6 thai gian tiem tang xuat hi~n phan v~. . B'ang 3 8ac tlttem cuap,h'an ve gjh'I nhan trong b"aocao v A' • A A Ty I~ (0/0) SoBC phan NQidung (n= v~ 10027) Bieu hien eua phan ve H~ tim m~eh: h~ huyet ap, m~ch nhanh, nhip tim nhanh, lo~n nhip, m~d 7542 75.2 cham khonQbat du'dc, dai tieu tien khong tu' chu, nQat H~ ho hap: suy ho hap, kho tho, co that phe quan, tho khe, tho rft, thanh 7481 74.6 Quansu'ng, phu du'onQho hap Da/niem mac: ban do, me day, phu mach, nglta da, do va nglta mat 5576 55.6 He tieu h6a: dau thu'dng vi, tieu chay, non lien tuc, dau bl,lngdG'd6i 2729 27.2 Bieu hi~n khae: v~t va, va rna hoi, suy da t~ng, ret run, sot cao, hoa 2966 29.6 mat, chong mat, gong cltng ngu'ai Mlte do nghiem trong ella phim ve phan loai theo Brown [3] Nghiem trong mlte do 1 5376 53.6 Ha huyet ap nghiem trQng 3851 38.4 Bieu hien thieu oxY mau 1701 17.0 Bieu hien tren he TKTW 1367 13.6 Nghiem trong mlte do 2 4632 46,2 Khong xae dinh du'de 19 0l_2 Mlte do nghiem trong e(la phim ve phan loai theo bieu mau bao eao ADR Tuvong 156 1,6 De doa tfnh mang 5069 50,6 Nhap vien/keo dai thoi Qian nam vien 1697 16,9 ran tat vinh vien/nanQ ne 43 0,4 Khong nghiem trong 2021 20,2 Khong r6 13 0,1 Kh6ng co thong tin 1028 10,3 . , .'" Phan v~ thu'ong du'c;1cbleu hl~n pho bien A .A .A nhat A A , ,. '" tren h~ tim m~ch (75,2%) va h~ ho hap'" A (74,6%) . Tri~u ch((ng tren da ho~c niem m~c du'c;1c ghi nh~n tren 55,6% so bao cao, tren tieu hoa (27,2%),cac bieu hi~n khac (29,6%). Cac bao cao co bieu hi~n nghiem trQng mltc 1 chiem 53,6% voi tl,lt huyet ap nghiem trQng 113bieu hi~n pho biet nhat, chiem 38,4%. Bieu hi~n thieu oxy va thieu mau chiem ran 1u'c;1t 17,0% va 13,6%. Da so phan v~ du'c;1c can bQy te danh gia la nghiem trQng, chi co 20,2% phan v~ du'c;1C coi 113kh6ng nghiem trQng. 326
TAP CHi Y HOC VIET NAM TAp 496· THANG 11·562·2020 Bang 4. Dac diem ve xu tri phan ve ghi nhan trona bao ceo jry I~ (0/0 each xU'tri Sa Be Ty I~ (%) Kit qua sau xU'tri Sa Be (n= phi," v~ (n= tOO27) phan v~ tOO27) Corticoid 7294 72,7 TU'vong 163 f,6 Adrenalin 6834 68,2 Chua hoi phuc 253 2',5 Lieu phap oxy 4710 47,0 Dang hoi phuc 3203 31;9 Khang histamin Hl va H2 4658 46,4 Hoi phuc co di chunq 92 0,9 Truven dich 4159 41;5 Hoi phuc khong co di chung 5383 53,7 Trung tâm DI&ADR Quốc gia - Tài liệu chia sẻ tại CANHGIACDUOC.ORG.VN và facebook CANHGIACDUOC Thuoc khac 790 7,9 Khong ra 200 2,0 Kich thich beta 2 400 4;0 Khono co thong tin 733 7,3 Van mach khac , 366 , 3,7 , A .~ ~ A , , A ~ .~ C~rtlcold va,adrenal,1nI~ du'Q'c~u dunq p~o bien nhe~de xu tnAphan,v~, la~ 1u'Q'tchlern 72,7% va 68!! Vo., K:t 9ua s~u ~utn ch? thay ca~ tru'ong hop hOI phuc khong co di chung va dang hoi phuc chiem tV I~ Ion nhat, Ian 1u'Q'tla 53,7% va 31,9%. Co 163 ca ghi nhan tu vong ung vai 1,6%. . IV. BAN LU~N . cac tru'ong hop nhi~m khuan n~ng. Ngu'Q'clC;lithi Nghien CtIUda cho thay so 1u'Q'ng bao cao lien penicilin la mQt thuoc da du'Q'ccanh bao nhieu ve quan den phsn v~ ghi nh~n du'Q'ctang theo thai c~c tru'ong hQ'pphsn v~ do do ft du'Q'ccan be?y gian trong 10 nam khso sat. Khang sinh trong do te h/a chQnsu dl,Jngtrong dieu trio nhom cephalosporin va carbapenem du'Q'cghi Nhom thu5c co so bao cao phsn v~ CqO'thu nh~n la cac thuOc pho bien nhat lien quan den hai trong cd so dCi' Ii~u la thu5c csn quang phsn ung phsn v~. Bh~uhi~n cua phsn v~ da (5,3%)" trong do dung dau la iobitridol (2,5%). dC;lngva xuat hi~n chu yeu tren h~ ho hap va tim Theo ca:: nghien nay, iopromid la thuoc csn mC;lch.Phan Ian cac phsn ung 0 muc de?nghiem qu~ng lien quan den nhieu tru'ong hQ'pphsn v~ trQng va du'Q'CxU' trf bang adrenalin cung nhat, trong khi nghien cuu cua ch(mg toi corticoid. Da co 1,6% so bao cao ghi nhan benh iopromid chi dung thu 2 vai 1,1%. Su' khac biet nhan tU'vong. . . nat co the den tlt vi~c iobitridol du'~c sU'dl,m'g So 1u'Q'ng bao cao phsn v~ tang dan theo tltng nhieu hdn i
VIETNAM MEDICAL JOURNAL N°2 • NOVEMBER· 2020 d§ tung gay di ((ng (1,6%) ho~c thuoc cling do phan v~ tat cac don vi dieu trio nhorn voi thuoc gay di ((ng (2,0%). TAl LIEU THAM KHAo Nghien cuu cua chung toi cling ghi nhan 1. BOY te (~017~, Thana tu' sO 51/2017{1T-BYTve vi~ 72,7% tnJ'ong hop str dunq corticoid, 68,2% sU' " HtJ'angdan phong,chandeanva xU'trl phan v~". dunq adrenalin. Con ket qua trong nghien ciru a 2. Le Thj Thuy Linh (2015), "Danh gia sl/ hinh Trung QUoc, tY I~ benh nhan sU'dunq adrenalin thanh tin hi~\.Jva cacf xU'tn cac tnlonq hop phan la 59,5%. Trong mQt so nqhlen cuu khac, bien v~ nr dO',li~l!, bao cao ADR tl/ nguy,~n tal Vi~t phep dlJ'qc sU' dunq nhieu nha't la corticoid va Nam", Luc;tnvan thac si duoc hoc, TrtJ'dngDc;tihoc Duoc Ha Nai. khanq histamin Hl, tuy nhien ngoai adrenalin 3. Brown S: G. (2004), "Clinical features and cac bi~n phap tren phI,!thuQc vao bieu hi~n phan severity grading of anaphylaxis", J Allergy Clin Trung tâm DI&ADR Quốc gia - Tài liệu chia sẻ tại CANHGIACDUOC.ORG.VN và facebook CANHGIACDUOC v~ va cach xU'tri clla bac si nen tY I~ giiIa cac Immunol, 114(2), pp. 371-6. nghien c((u chenh I~ch nhieu. NhlJ'v®y, vi~c dao 4. Nguyen K. D., Nguyen H. A., et al. (2019), "Drug-Induced Anaphylaxis in a Vietnamese t~o dinh ky nham giup can bQ y te t~i cac cd so Pharmacovigilance Database: Trends and Specific kham chiIa b~nh nam viIng kien th((c ve phat Signals from a Disproportionality Analysis", Drug hien va xU'trf la van de can thiet neu muon tang Saf, 42(5), pp. 671-682. tY 'I~ xU'trf phu h