TOPical Imiquimod treatment of high-grade cervical intraepithelial neoplasia (TOPIC trial): Study protocol for a randomized controlled trial

Cervical intraepithelial neoplasia (CIN) is the premalignant condition of cervical cancer. Whereas not all high grade CIN lesions progress to cervical cancer, the natural history and risk of progression of individual lesions remain unpredictable.