Trường Hợp Lâm Sàng Dùng Warfarin
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Anyway, I have 2 cases of patients who are on long-term Coumadin therapy. The INR results make us wonder about the use of multiple CYP2C9 inhibitors with wafarin... Patient #1: 75 yo caucasian male with afib. Warfarin dosed at 24 mg/wk, chronically on Amiodarone ( 10 years d/t hx of ventricular arrhythmias). Started Bactrim DS x10 days on Jan 25th. He notified anticoag clinic on Jan 29th and his dose was reduced by 50% for 2 days and INR checked yesterday (day 6 of Bactrim). One would expect the INR to be somewhat elevated considering Bactrim-warfarin interaction, but INR...
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