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2 inhibitor
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In patients with previously treated RAS-mutated microsatellite-stable (MSS) metastatic colorectal cancer (mCRC), a multicenter open-label phase 1b/2 trial was conducted to define the safety and efficacy of the MEK1/MEK2 inhibitor binimetinib in combination with the immune checkpoint inhibitor (ICI) nivolumab (anti–PD-1) or nivolumab and another ICI, ipilimumab (anti-CTLA4).
10p
vishanshan
27-06-2024
3
1
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In this work, the electrochemical behavior of carbon steel, brass, bronze and aluminum alloys in the presence of various important organic acids (sebacic acid (SbA), terephthalic (TPA), 2-ethylhexanoic (E2C6A), and octanoic (C8A)) and the effect that these have on the growth and protectiveness of the alloys have been investigated.
10p
viamancio
04-06-2024
1
0
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The basic aim of this study was to compare the denitrification efficacy of 2,5-dichloroaniline, Ammonium Thiosulphate and their combination (1:1) with previous studies. Ammonium Thiosulphate was not used as a nitrification inhibitor in previous research. Our findings depict that there was significant variation among the chemicals, soil and levels in denitrification for early seedling growth of wheat.
8p
dianmotminh02
03-05-2024
4
1
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In silico screening of alkaloids as potential inhibitors of HER2 protein for breast cancer treatment
his study focused on finding alkaloid compounds collected from Chemfaces database that inhibit HER2 enzyme employing computational methods such as molecular docking and ADMET prediction. Out of 118 phytochemicals docked to the ATP binding site of the HER2 kinase domain, 10 alkaloid compounds exhibited higher binding affinity than the reference inhibitor and satisfied the Lipinski’s rule of five. All compounds have good pharmacokinetic properties.
10p
dianmotminh02
03-05-2024
4
3
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Part 2 book "Cardiac drug therapy" includes content: Beta blockers: Angina, myocardial infarction, heart failure, heart failure controversies, arrhythmias, cardiac arrest, infective endocarditis, dyslipidemias, endocrine heart diseases, antiplatelet agents, anticoagulants, factor xa inhibitors, and thrombin inhibitors cardiac drugs during pregnancy and lactation drug interactions, hallmark clinical trials.
470p
zizaybay1101
30-04-2024
3
2
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Part 1 book "Petroleum Engineer's guide to oil field chemicals and fluids" includes content: Drilling muds, fluid loss additives, clay stabilization, lubricants, bacteria control corrosion inhibitors, scale inhibitors, gelling agents, filter cake removal, cement additives, transport, drag reducers.
404p
muasambanhan10
06-04-2024
2
0
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The discovery of synthetic lethal interactions between poly (ADP-ribose) polymerase (PARP) inhibitors and BRCA genes, which are involved in homologous recombination, led to the approval of PARP inhibition as a monotherapy for patients with BRCA1/2-mutated breast or ovarian cancer.
12p
vibransone
28-03-2024
3
2
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Whether elevated blood pressure (BP) is a modifiable risk factor for atrial fibrillation (AF) is not established. We tested (1) whether the association between BP and risk of AF is causal, (2) whether it varies according to individual’s genetic susceptibility for AF, and (3) the extent to which specific BP-lowering drugs are expected to reduce this risk.
10p
vibransone
28-03-2024
3
2
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A complex set of perturbations occur in cytokines and hormones in the etiopathogenesis of obesity and related cardiometabolic conditions such as type 2 diabetes (T2D). Evidence for the genetic regulation of these cytokines and hormones is limited, particularly in African-ancestry populations. In order to improve our understanding of the biology of cardiometabolic traits.
21p
vibransone
28-03-2024
2
2
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Although anti-apoptotic proteins of the B-cell lymphoma-2 (BCL2) family have been utilized as therapeutic targets in acute myeloid leukaemia (AML), their complicated regulatory networks make individualized therapy difficult.
13p
viellison
28-03-2024
2
2
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Ebook "Protein-Protein interactions (Topics in Medicinal chemistry, Volume 8)" surveys the field of inhibitors of the MDM2/p53 interaction, which essentially began with the high-profile disclosure of Nutlins, and quickly and steadily grew through programs at a number of pharmaceutical companies. The MDM2/p53 interaction constitutes a paradigm example of a relatively large, hydrophobic interaction surface for which lead compounds can easily be found.
276p
coduathanh1122
27-03-2024
5
1
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Sodium–glucose cotransporter 2 inhibitors are among the new-generation oral antihyperglycemic agents that have been used in the treatment of type 2 diabetes mellitus. With the recent coronavirus disease 2019 pandemic and rise of cases in the third wave, diagnosis of life-threatening euglycemic diabetic ketoacidosis may easily be overlooked or missed.
5p
vigojek
02-02-2024
4
1
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Ovarian cancer is metastatic at presentation in about 62% of cases, but brain metastases are rare, reported in 3.3–4% of patients. Brain metastasis seems to be more frequent in advanced stages at diagnosis and in patients with BRCA1/2 mutation.
5p
vitiki
30-01-2024
4
2
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We describe a case report of a patient with type 2 diabetes on sodium-glucose cotransporter 2 inhibitor and metformin therapy fasting for Ramadan (a holy month observed in the Islamic nation) diagnosed with euglycemic diabetic ketoacidosis.
5p
vitiki
30-01-2024
2
2
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The BRCA2 gene is a well-known tumor suppressor gene implicated in breast and ovarian cancers. BRCA1/2 mutations can be sensitive to poly ADP-ribose polymerase (PARP) inhibitors such as olaparib. However, some of these patients develop resistance to this treatment and an essential factor contributing to acquired insensitivity is the occurrence of reversion mutations in the BRCA1/2 genes.
5p
vitiki
30-01-2024
3
2
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Current guidelines for non-small-cell lung cancer (NSCLC) recommend that each tyrosine kinase inhibitor (TKI) is indicated even for driver mutation-positive patients with a poor performance status (PS). In previous studies, most patients had a PS of 2–3, but those with a PS of 4 were very few. Therefore, the efcacy of TKIs in patients with NSCLC with a PS of 4 remains unclear.
9p
vitiki
30-01-2024
2
2
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In clinical trials, poly (ADP-ribose) polymerase inhibitors (PARPi) versus chemotherapy resulted in significantly improved progression-free survival, manageable adverse event profiles, and favorable patient-reported outcomes (PROs) in patients with human epidermal growth factor receptor 2–negative (HER2−) advanced breast cancer (ABC) and germline BRCA1/2 mutations (gBRCA1/2mut).
10p
vileonardodavinci
23-12-2023
2
2
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Breast cancer (BC) is the most common malignant tumor among women worldwide. Tissue transglutaminase 2 (TG2) has been reported as a major player across several types of cancer. However, the effects of TG2 in breast cancer are less known.
11p
vileonardodavinci
23-12-2023
3
2
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Renal artery stenosis is responsible for approximately 75% of secondary hypertensive cases. A 63- year-old female patient with uncontrolled hypertension and other comorbidities including type 2 diabetes mellitus and knee osteoarthritis presented with drastically raised systolic blood pressure in this case report (220 mmHg).
4p
vikissinger
21-12-2023
2
1
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Bilateral breast cancer (BBC), as well as ovarian cancer, are significantly associated with germline deleterious variants in BRCA1/2, while BRCA1/2 germline deleterious variants carriers can exquisitely benefit from poly (ADP-ribose) polymerase (PARP) inhibitors. However, formal genetic testing could not be carried out for all patients due to extensive use of healthcare resources, which in turn results in high medical costs.
11p
vileonardodavinci
23-12-2023
10
4
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