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3D in vitro cancer models
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Recapitulating the tumor microenvironment (TME) in vitro remains a major hurdle in cancer research. In recent years, there have been significant strides in this area, particularly with the emergence of 3D spheroids as a model system for drug screening and therapeutics development for solid tumors. However, incorporating macrophages into these spheroid cultures poses specific challenges due to the intricate interactions between macrophages and cancer cells.
17p
vileonardodavinci
23-12-2023
4
2
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Drug testing in vitro cell culture models more accurately would be of significant value to the medical field and pharmaceutical industry. To achieve this goal, microfluidic cell culture platforms are created and improved for modeling the native cell microenvironment because they can precisely reconstruct in vivo cellular behavior.
10p
viannee
02-08-2023
6
3
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The mechanisms of action and efficacy of cisplatin and paclitaxel at cell population level are well studied and documented, however the localized spatio-temporal effects of the drugs are less well understood. We explore the emergence of spatially preferential drug efficacy resulting from variations in mechanisms of cell-drug interactions.
16p
vichaeng2711
29-04-2021
9
1
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Antibodies revolutionized cancer treatment over the past decades. Despite their successfully application, there are still challenges to overcome to improve efficacy, such as the heterogeneous distribution of antibodies within tumors.
19p
vikentucky2711
24-11-2020
7
1
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The benefit of better ballistic and higher efficiency of carbon ions for cancer treatment (hadron-therapy) is asserted since decades, especially for unresectable or resistant tumors like sarcomas. However, hadron-therapy with carbon ions stays underused and raises some concerns about potential side effects for patients.
14p
viamsterdam
18-09-2020
9
0
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Galectin-1 (gal-1) belongs to the family of β-galactoside-binding proteins which primarily recognizes the Galβ1-4GlcNAc sequences of oligosaccharides associated with several cell surface glycoconjugates. The lectin recognizes correspondent glycoepitopes on human breast cancer cells.
9p
vimale2711
25-08-2020
11
1
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Different 3D-cell culture approaches with varying degrees of complexity have been developed to serve as melanoma models for drug testing or mechanistic studies.
14p
vikuala271
13-06-2020
6
0
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Lung cancer is the leading cause of cancer-related deaths worldwide. This study focuses on its most common form, Non-Small-Cell Lung Cancer (NSCLC). No cure exists for advanced NSCLC, and patient prognosis is extremely poor.
21p
vikuala271
13-06-2020
13
1
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The human pancreatic cancer cell line A818–6 can be grown in vitro either as a highly malignant, undifferentiated monolayer (ML) or as three-dimensional (3D) single layer hollow spheres (HS) simulating a benign, highly differentiated, duct-like pancreatic epithelial structure.
17p
vijakarta2711
09-06-2020
7
0
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Pancreatic ductal adenocarcinoma is a devastating disease with poor outcome, generally characterized by an excessive stroma component. The purpose of this study was to develop a simple and reproducible in vitro 3D assay employing the main constituents of pancreatic ductal adenocarcinoma, namely pancreatic stellate and cancer cells.
13p
viorochimaru2711
01-06-2020
11
1
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In recent years, three-dimensional (3D) in vitro tumor models have become more common in cancer research across the world. Selecting scaffolds, seeding cells into the scaffolds, and culturing them are pivotal for the morphologies and proliferation of cancer cell lines. Therefore, this experience has developed a 3D tumor model based on co-culturing MCF-7 cells and fibroblasts (3:1) into gelatin-alginate scaffolds (3x3x5 mm3 ).
6p
caygaocaolon1
13-11-2019
18
2
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α-Mangostin (αMG) is extracted from Garcinia mangostana Linn and exerts antiproliferative activities. Although several researches on αMG were performed using cell monolayers, the in vitro pharmacological effects on 3D cancer models have never been investigated.
8p
vinasaki2711
12-11-2019
11
0
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