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5’ cytosine
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Ebook "Analytics of Protein–DNA interactions (Advances in biochemical engineering/biotechnology, Volume 104)" focuses on the fascinating possibilities that emerged during the last years to study protein–DNA interactions in vitro. As an essential part of transcriptional activity during development and in tumorgenesis a separate chapter describing the analysis of DNA modification especially methylation of cytosines at their carbon-5 position was included.
212p
manmanthanhla0201
27-02-2024
4
2
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Myelodysplastic Neoplasms (MDS) are clonal stem cell disorders characterized by ineffective hematopoiesis and progression to acute myeloid leukemia, myelodysplasia-related (AML-MR). A major mechanism of pathogenesis of MDS is the aberration of the epigenetic landscape of the hematopoietic stem cells and/or progenitor cells, especially DNA cytosine methylation, and demethylation.
18p
vialfrednobel
23-12-2023
4
3
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Study of epigenetics is currently a high-impact research topic. Multi stage methylation is also an area of high-dimensional prospect. In this article, we provide a new study (intra and inter-species study) on brain tissue between human and rhesus on two methylation cytosine variants based data-profiles (viz., 5-hydroxymethylcytosine (5hmC) and 5-methylcytosine (5mC) samples) through TF-miRNA-gene network based module detection.
22p
vinarcissa
21-03-2023
1
1
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GAW20 working group 5 brought together researchers who contributed 7 papers with the aim of evaluating methods to detect genetic by epigenetic interactions. GAW20 distributed real data from the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study, including single-nucleotide polymorphism (SNP) markers, methylation (cytosine-phosphate-guanine [CpG]) markers, and phenotype information on up to 995 individuals.
7p
vihagrid
30-01-2023
5
3
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DNA methylation is a heritable epigenetic mark, enabling stable but reversible gene repression. In mammalian cells, DNA methyltransferases (DNMTs) are responsible for modifying cytosine to 5-methylcytosine (5mC), which can be further oxidized by the TET dioxygenases to ultimately cause DNA demethylation.
15p
vigalileogalilei
27-02-2022
17
1
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5-fluorocytosine is a pyrimidine and a fluorinated cytosine analog mainly used as an antifungal agent. It is a precursor of 5-fluorouracil, which possesses anticancer properties. To reduce systemic toxicity of 5-fluorouracil during chemotherapy, 5- fluorocytosine can be used as a targeted anticancer agent.
10p
vidarwin
23-02-2022
15
1
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Recent work has identified and mapped a range of posttranscriptional modifications in mRNA, including methylation of the N6 and N1 positions in adenine, pseudouridylation, and methylation of carbon 5 in cytosine (m5C).
16p
vialfrednobel
29-01-2022
7
0
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Genome-wide methylation of cytosine can be modulated in the presence of TET and thymine DNA glycosylase (TDG) enzymes. TET is able to oxidise 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). TDG can excise the oxidative products 5fC and 5caC, initiating base excision repair.
9p
viaristotle
29-01-2022
3
0
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DNA methylation is an epigenetic event that adds a methyl-group to the 5’ cytosine. This epigenetic modification can significantly affect gene expression in both normal and diseased cells.
9p
viwyoming2711
16-12-2020
10
0
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As one of the most common post-transcriptional modifications (PTCM) in RNA, 5-cytosine-methylation plays important roles in many biological functions such as RNA metabolism and cell fate decision.
21p
vikentucky2711
24-11-2020
9
1
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The cytosine deaminase (CD)/5-fluorocytosine (5-FC) system is among the best explored enzyme/ prodrug systems in the field of the suicide gene therapy.
11p
viputrajaya2711
22-06-2020
5
0
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Post-transcriptional methylation of RNA cytosine residues to 5-methylcytosine (m5 C) is an important modification that regulates RNA metabolism and occurs in both eukaryotes and prokaryotes. Yet, to date, no transcriptome-wide identification of m5 C sites has been undertaken in plants.
17p
vihashirama2711
21-05-2020
16
1
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Adenoviruses tái tổ hợp là những công cụ đa năng để vận chuyển và biểu hiện gen. Ad vector đã được thử nghiệm như hệ chuyển vaccine trong một số nghiên cứu tiền lâm sàng và lâm sàng cho các bệnh truyền nhiễm như sởi, viêm gan B, bệnh dại, bệnh than, Ebola, SARS, HIV-1, sốt rét, lao và cúm. Cùng với sự phát triển của kỹ thuật di truyền, các vectors adenovirus thế hệ 1, 2, 3 lần lượt ra đời, đáp ứng những đòi hỏi khắt khe của một vector biểu hiện gen.
15p
ketaucho
20-11-2019
86
2
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Cytosine 5 DNA methyltransferases share ten conserved motifs. Motif IV contains an absolutely conserved proline-cysteine dipeptide. The cysteine residue of this motif is involved in catalysis by forming a covalent bond with the 6-position of cytosine prior to methyl group transfer.
8p
caplock2711
19-02-2019
12
0
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At the chromatin level, methylated CpG dinucleotides are R.Msp1 resistant compared with nonmethylated counterparts. The DNA of two E.coli strains was analyzed following transformationwith bacterial cytosine-5-methyltransferase gene M.Msp1 in mammalian transfection vector pcDNA3.
9p
vitamix
19-02-2019
24
0
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In the present study, we have been able to transfect and express the monospecific bacterial (Moroxcella spp) cytosine-5 DNA methyltransferase (MTase) M.Msp1 gene in cultured cells within a newly constructed mammalian transfection vector.
10p
vitamix
19-02-2019
12
1
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We have previously shown that DNA damage induced by doxorubicin was associated with an increase in the level of DNA methylation, 5meC, in mouse embryonic fibroblasts using a developed immunostaining methodology.
12p
nutifooddau
27-01-2019
20
2
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EcoRII DNA methyltransferase (M.EcoRII) recognizes the 5¢…CC*T/AGG…3¢ DNA sequence and catalyzes the transfer of the methyl group fromS-adenosyl-L-methionine to the C5 position of the inner cytosine residue (C*). Here, we study themechanismof inhibitionofM.EcoRII byDNA containing 2-pyrimidinone, a cytosine analogue lacking an NH2 group at the C4 position of the pyrimidine ring. Also, DNA containing 2-pyrimidinone was used for probing contacts ofM.EcoRII with functional groups of pyrimidine bases of the recognition sequence....
9p
dell39
03-04-2013
33
3
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DNA methylation is an important mechanism involved in embryogenesis and tumor development. Changing cytosines to 5-methylcytosines in CpG dinucleotides has been found to be responsible for the inactivation of tumor suppressor genes by repressing transcription.
15p
media19
04-03-2013
32
1
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Cytosine methylation at the 5-carbon position is the only known stable base modification found in the mammalian genome. The organization and modification of chromatin is a key factor in programming gene expression patterns. Recent findings suggest that DNA methylation at the junction of transcription initiation and elongation plays a critical role in suppression of transcription.
22p
vinaphone15
28-02-2013
39
2
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