Activation mechanism
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5-Fluorouracil (5FU) is a primary chemotherapeutic agent used to treat oral squamous cell carcinoma (OSCC). However, the development of drug resistance has significantly limited its clinical application. Therefore, there is an urgent need to determine the mechanisms underlying drug resistance and identify effective targets.
16p vishanshan 27-06-2024 2 1 Download
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This study aims to investigate the role and mechanism of tubiquitin-conjugating enzyme E2 C (UBE2C) in acute myeloid leukemia (AML). Initially, UBE2C expression in leukemia was analyzed using the Cancer Genome Atlas database. Further, we silenced UBE2C expression using small-hairpin RNA (sh-RNA).
11p vishanshan 27-06-2024 1 1 Download
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GEFT is a key regulator of tumorigenesis in rhabdomyosarcoma (RMS), and overexpression of GEFT is significantly correlated with distant metastasis, lymph node metastasis, and a poor prognosis, yet the underlying molecular mechanism is still poorly understood. This study aimed to investigate and validate the molecular mechanism of GEFT-activated lncRNAs in regulating mTOR expression to promote the progression of RMS.
16p vishanshan 27-06-2024 2 1 Download
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This article gives an overview of the mechanism and the correlation between the intensity of physical activity and detailed blood lipids. Physical activity is still an important non-pharmacological treatment, even for people with disabilities, or with chronic diseases.
12p vikoch 27-06-2024 1 1 Download
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This study aimed to explore the effect of CD276 expression on the sunitinib sensitivity of clear cell renal cell carcinoma (ccRCC) cell and animal models and the potential mechanisms involved.
15p vikoch 27-06-2024 1 1 Download
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Triple-negative breast cancer (TNBC) is the most lethal subtype of breast cancer (BC). The circRNAmiRNA‒mRNA axis is a promising biomarker for the early diagnosis and prognosis of BC. However, the critical circRNA mediators involved in TNBC progression and the underlying regulatory mechanism involved remain largely unclear.
11p vikoch 27-06-2024 1 1 Download
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This study aims to identify functionally relevant lncRNAs impacting OS proliferation and lipid metabolism and seeks to shed light on the upstream regulatory mechanisms governing lipogenic enzyme activity. Based on comprehensive bioinformatic analysis and the establishment of a risk model, we identified seven lncRNAs signifcantly associated with clinical characteristics and lipid metabolism-related genes in patients with OS.
15p vikoch 27-06-2024 1 1 Download
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High levels of physical activity are associated with reduced risk of the blood cancer multiple myeloma (MM). MM is preceded by the asymptomatic stages of monoclonal gammopathy of undetermined significance (MGUS) and smouldering multiple myeloma (SMM) which are clinically managed by watchful waiting.
18p vikoch 27-06-2024 1 1 Download
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TCP-targeted low-rate distributed denial-of-service (LDDoS) attacks pose a serious challenge to the reliability and security of the Internet. Among various proposed solutions, we are particularly interested in the Congestion Participation Rate (CPR) metric and the CPR-based approach.
17p viambani 18-06-2024 2 1 Download
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This volume describes the mechanisms which bacteria have created to secure their survival, proliferation and dissemination by subverting the actin cytoskeleton of host cells. Bacteria have developed a veritable arsenal of toxins, effector proteins and virulence factors that allow them to modify the properties of the intracellular actin cytoskeleton for their own purposes.
249p vimeyers 29-05-2024 3 2 Download
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Ebook "River dynamics and integrated river management" provides comprehensive information on rivers for integrated management, including natural processes, stresses resulting from human activities, and restoration of various parts of the river basin, including the watershed, mountain streams, alluvial rivers, estuaries, and natural and man-made lakes.
855p giangdongdinh 28-05-2024 5 1 Download
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This study will present the current status of the management and legal framework in providing solutions to support banking activities of Fintech companies in Vietnam, thereby assessing the limitations and challenges of the legal framework. in providing solutions to support banking cooperation of Fintech companies. From there, the author proposes solutions on management mechanisms for service solutions related to e-KYC, Open API and build an Innovation Center in the banking sector to promote the cooperation between Fintech companies and Banks to complete the Fintech Ecosystem in Vietnam.
11p dathienlang1012 03-05-2024 2 0 Download
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In this study, three-dimensional crystal plasticity finite element method (CPFEM) simulations of the nanoindentation test on zinc single crystal have been implemented in the finite element code Abaqus using a user material subroutine. The basics of deformation mechanisms of zinc, nanoindentation test and crystal plasticity theory will be presented.
10p dathienlang1012 03-05-2024 0 0 Download
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The efficient synthesis of 12-substituted-3,4,4a,5,12,12a-hexahydrobenzo[b]acridine-1,6,11(2H)-triones starting from 2-amino-1,4-naphthoquinone, 1,3-cyclohexanedione, and different (hetero)aromatic aldehydes was developed. These reactions were carried out in acetic acid under microwave irradiation in the presence of p-toluenesulfonic acid as catalyst. The structure of the newly synthesized compounds were confirmed employing spectroscopic data as well as elemental analysis. The plausible mechanism of these three-component domino reactions was also described.
7p dianmotminh02 03-05-2024 4 1 Download
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Antibacterial packaging represents an active packaging solution crafted to uphold the quality and safety of products. One of the popular polymer used in food packaging is Linear Low-Density Polyethylene (LLDPE), due to its low cost, ease of processing, and high mechanical properties. Polymer blend based on LLDPE and antibacterial agent PHMG were prepared in the presence of PE-g_AM compatibilizer and DCP initiator.
6p dianmotminh02 03-05-2024 3 1 Download
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A simple and environment-friendly electrochemical method using activated glassy carbon electrodes (aGCE) for monitoring the residues of tetracycline in pork samples was developed. A two-step pretreatment procedure was established for activating the glassy carbon electrode surface, including mechanical polishing and electrochemical pretreatment. In the supporting electrolyte solution of 0.2 M sodium sulfate (at pH 2.5), the electrochemical response of TC was characterized by two irreversible oxidation peaks at +0.95 V and +1.05 V vs. saturated calomel electrode. T
9p dianmotminh02 03-05-2024 3 1 Download
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Ebook "The molecular mechanisms of axenfeld-rieger syndrome" presents detailed information and clinical descriptions and diagnosis of ARS, phenotypical descriptions of patients with ARS, molecular aspects of ARS and gene structure/function studies; describes state-of-the-art scientific methods used to assay genes, gene products and structure/function activities of transcription factors;...
115p tracanhphuonghoa1007 22-04-2024 4 2 Download
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Ebook "Acute neuronal injury: The role of excitotoxic programmed cell death mechanisms" is the result of a convergence of scientific information regarding mechanisms that produce acute nerve cell death in the brain.
303p tracanhphuonghoa1007 22-04-2024 4 3 Download
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Chemogenetic profiling enables the identification of gene mutations that enhance or suppress the activity of chemical compounds. This knowledge provides insights into drug mechanism of action, genetic vulnerabilities, and resistance mechanisms, all of which may help stratify patient populations and improve drug efficacy.
12p vibransone 28-03-2024 5 2 Download
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The main focus of the current study is to investigate the moderating role of operational control in the relationship between entrepreneurial activity and innovation performance. The present research aims to observe the association between antecedents and operations control mechanism, innovation performance, and corporate entrepreneurship.
9p longtimenosee07 29-03-2024 4 2 Download