Active pharmaceutical ingredient

Ebook "Flow chemistry for the synthesis of heterocycles" provides an overview of recent developments and scope in the use of flow chemistry in relevance to heterocyclic synthesis. The heterocyclic ring is the most prominent structural motif in the vast majority of natural products as well as pharmaceutical compounds since this facilitates tuneable interactions with the biological target besides conferring a degree of structural and metabolic stability.

400p tracanhphuonghoa1007 22-04-2024 6 3   Download

Ebook "Food physics: Physical properties – measurement and applications" deals with the physical properties of food, food ingredients and their measurement. Physical properties of food play a key role in all fields where modern technological processes are applied for the generation of food raw materials and the production of food. The determination of physical properties of food and related products are a pre-requisite for planning, production engineering and automation processes in today’s food, pharmaceutical and cosmetics industries as well as in all related quality control activities.

554p manmanthanhla0201 27-02-2024 7 2   Download

Simple, rapid, sensitive, precise and specific UV spectrophotometric method for the determination of isoniazid (INH) in active pharmaceutical ingredient were developed and validated. A simple double beam UV spectrophotometric method has been studied with different parameters such as linearity, precision, repeatability, accuracy as per ICH guidelines.

6p vibego 02-02-2024 1 0   Download

The increase in new cases of drug resistance to first-line drugs such as ethambutol (ETB) makes it necessary to develop improvements for antituberculosis drugs. A new method for improving the bioavailability of active pharmaceutical ingredient (API) was investigated for preventing drug resistance and side-effects of antituberculosis drugs. In this study, an antituberculosis drug delivery system using β-cyclodextrin (β-CD) as the supramolecular carrier of ETB was prepared using the kneading method.

10p lyhuyenthu 31-01-2023 3 1   Download

Intramuscular medroxyprogesterone acetate (MPA) products are commonly used to treat endometriosis and are the most widely used injectable contraceptives worldwide. Therefore, dependable quality screening of MPA injectables is a crucial measure necessary for ensuring that consumers are provided with safe and effective medications.

11p viginny 23-12-2022 8 3   Download

Support vector regression models are created and used to predict the retention times of oligonucleotides separated using gradient ion-pair chromatography with high accuracy. The experimental dataset consisted of fully phosphorothioated oligonucleotides. Two models were trained and validated using two pseudoorthogonal gradient modes and three gradient slopes.

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Separation of morphine and its impurities (related substances specified in relevant European Pharmacopoeia monographs, as well as the other naturally occurring coextracted alkaloids) was obtained within a close retention window on a reverse phase HPLC column, eluted with optimized gradient, consisting of methanol and 5 mM ammonium formate, adjusted to pH 10.2. Systematic optimization of the chromatographic conditions was carried out using design of experiments.

13p tudichquannguyet 29-11-2021 11 1   Download

The features of a drop-on-demand-based system developed for the manufacture of meltbased pharmaceuticals have been previously reported. In this paper, a supervisory control system, which is designed to ensure reproducible production of high quality of melt-based solid oral dosages, is presented. This control system enables the production of individual dosage forms with the desired critical quality attributes: amount of active ingredient and drug morphology by monitoring and controlling critical process parameters, such as drop size and product and process temperatures.

10p caothientrangnguyen 09-05-2020 13 0   Download

Griffithsin is a broad spectrum antiviral lectin that inhibits viral entry and maturation processes through binding clusters of oligomannose glycans on viral envelope glycoproteins.

10p viuchiha2711 21-04-2020 12 1   Download

Parasitic diseases are the main challenge of livestock production in the world. They are mainly controlled by the use of anthelmintic drugs. To be effective, the drugs should contain the appropriate amount of active pharmaceutical ingredient (API) and have the required physical characteristics.

7p vimax2711 27-03-2020 59 2   Download

In developing countries, brand-generic substitution is not based on validated scientific evidence that confirm the therapeutic equivalence of the generic to the originator. Rather, decisions are made based on the availability of generic medications. Substitution by inappropriate preparations applies to antibiotics, which may increase the risk of resistance in case of underdosing.

12p vimax2711 27-03-2020 10 1   Download

Fenugreek (Trigonellafoenum-graecum) is a legume and it has been used as a spice throughout the world to improve the sensory quality of foods. It is a medicinal plant that uses in disease some therapy. The plant contains active constituents such as alkaloids, flavonoids, steroids, Saponins etc. Fenugreek is known to have antidiabetic, anticarcinogenic, hypocholesterolemic, antioxidant, and immunological activities.

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The genus Litsea Lam. (Lauraceae) and Lepisanthes Blume (Sapindaceae) are wildly distributed in Vietnam, especially in the mountainous areas. The reports in the literatures indicated that these two genus contain many constituents with interesting structures and potential biological activities. In order to find interesting substances for development of new pharmaceutical ingredients or functional food products we would like to conduct the resarch thesis ‘‘Study on Chemical constituents and biological activities of Litsea glutinosa (Lour.) Rob. (Lauraceae) and Lepisanthes rubiginosa (Roxb.

26p xacxuoc4321 11-07-2019 26 6   Download

Quá trình nghiên cứu được thực hiện trên mẫu nước thải Nhà máy dược IMC - khu công nghiệp Quang Minh – Mê Linh – Hà Nội. Sản phẩm chủ yếu của Nhà máy là các loại thực phẩm chức năng và thuốc đông dược. Trong quá trình sản xuất, Nhà máy đã thải ra một lượng lớn nước thải có chứa các thành phần dược phẩm hoạt tính (Active Pharmaceutical Ingredients, APIs).

6p comamngo1902 30-03-2019 35 2   Download

Nabin’s current research will strike a chord with most people. He is tackling the pharmaceutical industry head-on by examining the issues surrounding generic alternatives in the purchase of prescription drugs. When people are asked if they would like a cheaper brand, they usually assume that the ingredients are the same, but the results of level trade tests have been surprising, he explains. ‘A recent medical journal confirmed that the active ingredients in the drugs are the same but the inactive ingredients are different.

51p lenh_hoi_xung 22-02-2013 44 1   Download

The Appendix consists of three tables. The first table lists the INNs of pharmaceutical active ingredients that are eligible for duty-free treatment. The second table consists of chemical prefixes and suffixes that may be combined with the INNs to specify pharmaceutical derivatives that are also included in the agreement. The third table specifies the chemical intermediates for which duties have been eliminated. U.S. imports of products included in the Pharmaceutical Appendix totaled over $85 billion in 2009; U.S. exports of these products exceeded $41 billion.

220p cao_can 29-12-2012 65 7   Download

Pharmaceutical products covered in the Pharmaceutical Zero-for-Zero Initiative can be imported either as bulk active ingredients or in dosage forms that can be packaged for retail sale. Products in dosage form are generally classified under chapter 30 of the HTS, where most of the subheadings are duty-free. Many of the bulk pharmaceutical active ingredients and chemical intermediates are classified under HTS subheadings that also contain non-pharmaceutical products and have rates of duty ranging from 0 to 6.5 percent ad valorem.

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Pharmaceutical Substances Syntheses, Patents, Applications - Part 237. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers.

10p pretty9 22-09-2010 67 2   Download

Pharmaceutical Substances Syntheses, Patents, Applications - Part 235. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers.

10p pretty9 22-09-2010 56 2   Download

Pharmaceutical Substances Syntheses, Patents, Applications - Part 234. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers.

10p pretty9 22-09-2010 100 2   Download