Activity limitations
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5-Fluorouracil (5FU) is a primary chemotherapeutic agent used to treat oral squamous cell carcinoma (OSCC). However, the development of drug resistance has significantly limited its clinical application. Therefore, there is an urgent need to determine the mechanisms underlying drug resistance and identify effective targets.
16p vishanshan 27-06-2024 2 1 Download
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Although immune cell therapy has long been used for treating solid cancer, its efficacy remains limited. Interferon (IFN)-producing killer dendritic cells (IKDCs) exhibit cytotoxicity and present antigens to relevant cells; thus, they can selectively induce tumor-associated antigen (TAA)-specific CD8 T cells and may be useful in cancer treatment.
12p vishanshan 27-06-2024 3 1 Download
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Effect of exercise-based cancer rehabilitation via telehealth: A systematic review and meta-analysis
Exercise-based cancer rehabilitation via digital technologies can provide a promising alternative to centrebased exercise training, but data for cancer patients and survivors are limited. We conducted a meta-analysis exam‑ ining the effect of telehealth exercise-based cancer rehabilitation in cancer survivors on cardiorespiratory fitness, physical activity, muscle strength, health-related quality of life, and self-reported symptoms.
16p vishanshan 27-06-2024 1 1 Download
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The prognosis of patients with Relapsed/Refractory Osteosarcoma (R/R OS) remains dismal without an agreement on systemic therapy. The use of High-Dose Ifosfamide (14 g/sqm) with an external pump in outpatient setting (14-IFO) in R/R OS patients is limited. This study represents the first retrospective cohort analysis focused on evaluating the activity and toxicity of 14-IFO in this setting.
12p vikoch 27-06-2024 1 1 Download
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The novel oncologic PET-tracer fibroblast activation protein inhibitor (FAPI) has demonstrated promising results in multiple cancer types, including ovarian cancer, and could overcome the limitations of [18F]FDG PET; however, high-quality clinical studies are lacking.
9p vikoch 27-06-2024 2 1 Download
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There are limited and no standard therapies for recurrent glioblastoma. We herein report the antitumour activity and safety of sintilimab, bevacizumab and temozolomide (TMZ) in recurrent glioblastoma.
10p vikoch 27-06-2024 1 1 Download
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Ebook "Beyond the limits to growth: New ideas for sustainability from Japan" offers an optimistic view of the future and provides a road map for societies to get there. Drawing upon extensive research and many years as a thought leader in environmental and sustainability issues in Japan and internationally, Hiroshi Komiyama analyzes the most pressing challenges to the attainment of sustainability of economically advanced nations and argues forcefully for Japan to lead them out of the present dilemma through active promotion of creative consumer and societal demand.
131p giangdongdinh 28-05-2024 3 1 Download
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This study will present the current status of the management and legal framework in providing solutions to support banking activities of Fintech companies in Vietnam, thereby assessing the limitations and challenges of the legal framework. in providing solutions to support banking cooperation of Fintech companies. From there, the author proposes solutions on management mechanisms for service solutions related to e-KYC, Open API and build an Innovation Center in the banking sector to promote the cooperation between Fintech companies and Banks to complete the Fintech Ecosystem in Vietnam.
11p dathienlang1012 03-05-2024 2 0 Download
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Lecturers need to change their teaching strategies to make students able to accept the material provided. On the other hand, students must manage their lives without being limited by space and time to avoid stress and cyberloafing, especially in the academic field.
11p viarnault 25-04-2024 3 1 Download
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Ebook "Communicable diseases of the developing world" reviews the current strategies and challenges for the treatment of bacterial, fungal, parasitic and viral infectious diseases in developing countries. Contributing authors present expert analysis on the transmission, epidemiology, bacteriology, pathogenesis and treatment of Neglected Tropical Bacterial Diseases such as Leprosy, Buruli ulcer, and Trachoma. Particular attention is also given to current antifungal agents, their spectrum of activity, mode of action, limitations, and current challenges in antifungal therapy.
258p tracanhphuonghoa1007 22-04-2024 6 3 Download
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Part 1 book "Analysis of electrical circuits with variable load regime parameters - Projective geometry method" includes content: Introduction, operating regimes of an active two pole display of projective geometry, generalized equivalent circuit of an active two pole with a variable element, two port circuits, paralleling of limited capacity voltage sources.
166p dianmotminh00 22-04-2024 5 4 Download
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Ebook "Amorphous drugs: Benefits and challenges" explains theoretical and technological aspects of amorphous drug formulations. It is intended for all those wishing to increase their knowledge in the field of amorphous pharmaceuticals. Conversion of crystalline material into the amorphous state, as described in this book, is a way to overcome limited water solubility of drug formulations, in this way enhancing the chemical activity and bioavailability inside the body.
234p tracanhphuonghoa1007 22-04-2024 6 3 Download
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In the article, we mention issues related to capital adequacy and financial safety of commercial banks, especially in the context of digitalization of banking and financial activities. Analyzing the current situation of capital adequacy in financial safety of Vietnamese commercial banks in the period 2011-2020. From the assessments through the success, limitation and cause, the article proposes 7 groups of solutions to ensure capital adequacy and enhance financial safety for Vietnamese commercial banks in the current context.
10p longtimenosee09 08-04-2024 3 1 Download
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This paper aims to research on moral hazard and moral risk management in business activities of commercial banks. From theory to practice, we could recognize the reality that Vietnamese commercial banks have faced many risks, especially moral hazard. Through practical analysis, from the achievements, limitations and causes, the article proposes some solutions to strengthen the management of moral risks in business activities of Vietnamese commercial banks in the coming time.
9p longtimenosee09 08-04-2024 10 2 Download
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Currently, accounting information provided for PPP activities at hospitals is not complete, timely, transparent, and especially does not reflect the true nature of PPP in healthcare. This stems from the fact that in Vietnam currently, Circular 107/2017/TT-BTC only provides accounting guidance for joint venture and association activities, but does not have specific accounting guidance for joint venture activities. Public-private cooperation in public service units. Therefore, the accounting work for this activity in many hospitals is really difficult.
6p longtimenosee09 08-04-2024 2 1 Download
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Head and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy characterized by tumor heterogeneity, locoregional metastases, and resistance to existing treatments. Although a number of genomic and molecular alterations associated with HNSCC have been identified, they have had limited impact on the clinical management of this disease.
18p vibransone 28-03-2024 9 2 Download
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Small cell lung cancer (SCLC) is a more aggressive subtype of lung cancer that often results in rapid tumor growth, early metastasis, and acquired therapeutic resistance. Consequently, such phenotypical characteristics of SCLC set limitations on viable procedural options, making it difficult to develop both screenings and effective treatments.
20p vibransone 28-03-2024 3 2 Download
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Ebook "A novel heme-thiolate peroxygenase AaeAPO and its implications for C–H activation chemistry" investigates the function and mechanism of a newly discovered heme-thiolate peroxygenase, AaeAPO. This enzyme class comes from Agrocybe aegerita and is used in the conversion of inert hydrocarbons to alcohols. Xiaoshi's work focuses on an extracellular P450 enzyme which is not limited in its stability and lack of solubility and therefore is relevant for widespread industrial use.
153p tudohanhtau1006 29-03-2024 1 1 Download
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Personalised dietary modulation of the gut microbiota may be key to disease management. Current investigations provide a broad understanding of the impact of diet on the composition and activity of the gut microbiota, yet detailed knowledge in applying diet as an actionable tool remains limited.
14p vibransone 28-03-2024 6 2 Download
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A complex set of perturbations occur in cytokines and hormones in the etiopathogenesis of obesity and related cardiometabolic conditions such as type 2 diabetes (T2D). Evidence for the genetic regulation of these cytokines and hormones is limited, particularly in African-ancestry populations. In order to improve our understanding of the biology of cardiometabolic traits.
21p vibransone 28-03-2024 2 2 Download