Acute lymphoblastic leukaemia
-
Children with acute lymphoblastic leukaemia (ALL) experience multiple symptoms that occur in complicated patterns and negatively affect patient outcomes. To date, no systematic review has been performed on the prevalence of symptoms in children with ALL.
15p vialfrednobel 23-12-2023 3 2 Download
-
Part 1 book "The genetic basis of haematological cancers" includes content: Molecular genetics of paediatric acute myeloid leukaemia, acute lymphoblastic leukaemia, the genetics of mature B-cell malignancies, the genetics of chronic myelogenous leukaemia.
180p oursky01 24-07-2023 8 3 Download
-
The numerous rising infections and deaths of malaria and acute lymphoblastic leukaemia (ALL) highlights the urgent need for early, useful, and efficient diagnosis methods. Recently, the framework of artificial intelligence has been applied to minimize time-consuming tasks, to increase the accuracy and flexibility of clinical diagnoses, and to reduce the pressure on physicians, diagnosticians, and clinical experts.
9p vicedric 08-02-2023 2 1 Download
-
The wealth of gene expression values being generated by high throughput microarray technologies leads to complex high dimensional datasets. Moreover, many cohorts have the problem of imbalanced classes where the number of patients belonging to each class is not the same.
10p viwyoming2711 16-12-2020 15 1 Download
-
Cognitive fatigue after childhood cancer is frequently overlooked despite guidelines recommending follow-up, and might be mistaken for depression due to overlapping symptoms. Our objectives were: 1) to examine ratings of fatigue in survivors of paediatric brain tumours (BT) and acute lymphoblastic leukaemia (ALL) compared to healthy controls, 2) to examine the relationship between symptoms of depression and cognitive fatigue, and 3) to evaluate parent-child concordance in ratings of cognitive fatigue.
9p vigeorgia2711 30-11-2020 13 2 Download
-
The prognosis for adult patients with Ph(-) B-precursor acute lymphoblastic leukaemia (ALL) who are refractory to treatment or experience relapse (R/R), is poor; over 90 % of these patients die from the disease, typically within a few months. While there are some national guidelines published for the treatment of adult patients with ALL, and local working group recommendations do exist, there is very little detail and no preferred treatment regimens for adult patients with R/R Ph(-) B-precursor ALL.
8p vimoscow2711 29-08-2020 9 0 Download
-
We examined incidence and survival in relation to age, gender, socioeconomic deprivation, rurality and trends over time. We also examined the association between volume of patients treated by hospitals and survival.
7p vibaku2711 22-07-2020 11 2 Download
-
Daunorubicin is commonly used in the treatment of acute lymphoblastic leukaemia (ALL). The aim of this study was to explore the kinetics of double strand break (DSB) formation of three ALL cell lines following exposure to daunorubicin and to investigate the effects of daunorubicin on the cell cycle and the protein kinases involved in specific checkpoints following DNA damage and recovery periods.
12p viputrajaya2711 22-06-2020 7 0 Download
-
TP53 mutations occur in only about 3% of primary and 10–20% of relapse B-cell precursor acute lymphoblastic leukaemia (BCP-ALL). However, alternative mechanisms may contribute to functionally impairing the p53 pathway in the absence of a mutation.
9p vikuala271 13-06-2020 7 2 Download
-
Acute T-cell lymphoblastic leukaemia (T-ALL) is an aggressive disorder derived from immature thymocytes. The variability observed in clinical responses on this type of tumours to treatments, the high toxicity of current protocols and the poor prognosis of patients with relapse or refractory make it urgent to find less toxic and more effective therapies in the context of a personalized medicine of precision.
10p vikuala271 13-06-2020 6 1 Download
-
The significance of very early chimerism assessment before day + 28, which is considered the moment of engraftment, is still unclear. In this retrospective study, we evaluated the clinical impact of very early chimerism on the clinical outcome after allogeneic haematopoietic stem cell transplantation (allo-HSCT) in children with acute lymphoblastic leukaemia (ALL).
8p vikuala271 13-06-2020 8 1 Download
-
Infection with varicella-zoster virus (VZV) contemporaneously with malignant disease or immunosuppression represents a particular challenge and requires individualized decisions and treatment.
7p virubber2711 21-03-2020 12 1 Download
-
l-Asparaginase (EC 3.5.1.1,l-ASNase) catalyses the hydrolysis ofl-Asn, producingl-Asp and ammonia. This enzyme is an anti-neoplastic agent; it is used extensively in the chemotherapy of acute lymphoblastic leukaemia. In this study, we describe the use of in vitro directed evolution to create a new enzyme variant with improved thermal stability.
12p vinaphone15 27-02-2013 51 3 Download
-
Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí hóa học đề tài : Effect of dexamethasone on quality of life in children with acute lymphoblastic leukaemia: a prospective observational study
8p dauphong10 31-01-2012 45 3 Download
-
Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí hóa học quốc tế đề tài : Effect of dexamethasone on quality of life in children with acute lymphoblastic leukaemia: a prospective observational study
8p panasonic07 04-01-2012 58 5 Download
-
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Acute disseminated encephalomyelitis mimicking late CNS relapse of acute lymphoblastic leukaemia: case report...
5p thulanh28 14-12-2011 56 2 Download
-
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: The impact of therapy for childhood acute lymphoblastic leukaemia on intelligence quotients; results of the risk-stratified randomized central nervous system treatment trial MRC UKALL XI...
12p thulanh25 06-12-2011 41 4 Download