Advanced pancreatic carcinoma

Obesity is a risk factor for developing pancreatic cancer. We investigated the impact of obesity on survival in patients diagnosed with locally advanced or metastatic pancreatic cancer. Methods: In a multicentre, retrospective study, we included all patients with advanced or metastatic pancreatic cancer treated at four Swiss hospitals between 1994 and 2004.

7p vilisa271 22-09-2020 5 0   Download

This uncommon type of skin cancer develops from neuroendocrine cells (hormone-making cells that resemble nerve cells in some ways) in the skin. They are most often found on the head, neck, and arms but can start anywhere. These cancers are thought to be caused in part by sun exposure and in part by Merkel cell polyomavirus (MCV). About 8 out of 10 Merkel cell carcinomas are thought to be related to MCV infection. MCV is a common virus. Many people are infected with MCV, but it usually causes no symptoms. In a small portion of people with this infection,...

537p khongmuonnghe 07-01-2013 46 4   Download

Pancreatic cancer is a leading cause of cancer-related deaths in the world with a 5-year survival rate of less than 6%. Currently, there is no successful therapeutic strategy for advanced pancreatic cancer, and new effective strategies are urgently needed.

17p vilisa271 22-09-2020 5 0   Download

Currently, adult cells seem to have certain advantages regarding rapid clinical translation. Most biomaterials used in Tissue Engineering are based on acellular matrices or polyglycolic acid. Both materials must provide tissue support until the cells produce their own extracellular matrix. Ideally, they degrade thereafter without any toxic byproducts. Over the last years we started to understand the influence of the biomechanical environment allowing these cell-biomaterial composites to unfold their full functional potential.

394p kmkmkmkmkm 08-09-2012 51 12   Download

Tham khảo sách 'committee on toxicity of chemicals in food, consumer products and the environment - subgroup report on the lowermoor water pollution incident', khoa học tự nhiên, công nghệ môi trường phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả

448p saimatkhauroi 01-02-2013 65 10   Download

The principal focus of American Independent Cinema is on the particular versions of independent cinema that came to prominence from the mid 1980s with the appearance of milestone films such as Stranger Than Paradise (Jim Jarmusch, 1984), sex, lies, and videotape (Steven Soderbergh, 1989) and Clerks (Kevin Smith, 1994).

0p khanhchilam 01-04-2013 60 5   Download

Intermediate-risk patients are those with any of the following criteria: microscopic tumour invasion into the perithyroidal tissues at initial surgery, cervical lymph node metastases or 131I uptake outside the thyroid bed on the initial post-treatment scan, or tumour with aggressive histology or vascular invasion. Finally, high-risk patients have macroscopic tumour invasion, incomplete tumour resection, distant metastases or elevated thyroglobulin out of proportion to what is seen on the post-treatment scan (Cooper et al., 2009).

398p wqwqwqwqwq 20-07-2012 69 4   Download

Changes in the pattern of DNA methylation are commonly seen in human tumors. Both genome wide hypomethylation (insufficient methylation) and region-specific hypermethylation (excessive methylation) have been suggested to play a role in carcinogenesis2. A common cause of the loss of tumor-suppressor miRNAs in cancer is the silencing of primary transcripts by CpG island promoter by hypermethylation3.

400p yeutinh98 22-09-2012 38 4   Download

Conventional approaches to health in poor countries focus on disease–specific interventions and their cost effectiveness, implemented via the path of least resistance with a strong emphasis on short term results. The upshot is that sys- temic problems which underlie poor health, failing health systems, and health inequity are circumvented. Long–term, sustainable strategies are rarely devel- oped or deployed. The crisis may change its spots, expressing itself in different diseases, populations or geographic areas, but it essentially continues unabated.

24p connicquy 20-12-2012 54 4   Download

The average number of living children is lower in Phnom Penh than in the five provinces. This apparently is the result of lower past fertility levels of current Phnom Penh elderly rather than higher losses of children through mortality. In fact, respondents in Phnom Penh report fewer deaths of their children than do those in the provinces (results not shown). Older elders average somewhat smaller numbers of surviving children than younger elders.

39p ut_hai_can 26-12-2012 33 4   Download

This system, designed in cooperation with the banking industry, is based on chipcard technology and corresponds to the electronic cash system above. The only difference is the possibility of offline authorisation. An authorisation up to a certain limit laid down individually by the issuing bank is stored on the bank card’s chip. This amount decreases with each payment and, as long as the remaining amount is sufficient, transactions are authorised offline. In order to pay, the customers must enter their PIN, which is validated on the chip.

165p enterroi 02-02-2013 31 4   Download

Services to implementing agencies. The limited capacity of implementing agencies to mainstream gender-responsive approach- es sometimes constrains the success of Bank projects and programs. The Bank itself has a limited capacity to provide technical assistance to implementing agencies, but one region has successfully estab- lished technical service facilities that rely on part-time consultants to advise these agencies on integrating gender-responsive approaches into project implementation.

138p machuavo 19-01-2013 41 4   Download

"Marketing" is defined as the aggregate of functions involved in transferring title and in moving goods from producer to consumer. Agricultural marketing2 includes such processes as assembling the raw commodities, grading, packaging, transportation, preparation for use, storage, shifting and sharing risks, change in ownership, pricing and exchange, wholesaling and retailing. One of the first steps in agricultural marketing is assembling the raw commodities.

17p nhacchovina 22-03-2013 39 4   Download

The contributors to the conference comprised a mixture of art historians, curators, museum studies lecturers, anthropologists, archaeologists and artists, and the conference timetable positioned established academics alongside scholars at an earlier stage in their research and writing careers.

16p yasuyidol 01-04-2013 35 4   Download

Traditionally, public transportation passenger cost savings were often the primary factors considered as the benefits of public transportation projects. This mindset has changed significantly and now it is widely accepted that public transportation investment can also help reduce roadway traffic congestion, with broader benefits for commercial truck deliveries, employer labor market access and on other aspects of business productivity.

77p trinhcaidat 19-04-2013 70 4   Download

A younger investor, less concerned about these issues, may not be sat- isfied with the lower expected return that inflation hedging implies. It follows from a model with additional hedge portfolios that an OE portfolio for performance evaluation should have the same exposures as the managed portfolio to be evaluated, not just with respect to the overall market, but also with respect to the other relevant risk factors. A related asset pricing model is the Arbitrage Pricing model of Ross (APT, 1976), which allows for several risk factors to determine assets’ expected returns.

34p quaivatdo 19-11-2012 41 3   Download

A representative random systematic sampling of clusters from 183 elderly people aged 65 and over was selected from the old age groups of Joaçaba, SC. Previous to the commencement of the research, workshops with the participants were conducted in order to discuss the method of performance of the interviews12. A pilot test was done to calibrate the 5 surveyors in relation to the observation of the clinical condition examined, and the (kappa) agreement test was used for these measurements until an adequate value was obtained.

5p thankinhphanliet 01-01-2013 46 3   Download

Although particle levels have declined substantially since the 1970s, particle pollution has shown no discernible trend over the last decade. The Air NEPM 1-day standard for PM10 is 50 µg/m3 and is not to be exceeded more than five times a year at any one site. The number of allowed exceedences takes into account bushfires and similar natural events and necessary bushfire hazard reduction burning. In 2001, exceedences occurred on 8 days in Sydney and 5 days in both the Lower Hunter and the Illawarra.

40p saimatkhauroi 01-02-2013 34 3   Download

We too believe that the global imbalances and the financial crisis are intimately connected, but we take a more nuanced stance on the nature of the connections. In our view, both originated primarily in economic policies followed in a number of countries in the 2000s (including the United States) and in distortions that influenced the transmission of these policies through U.S. and ultimately through global financial markets.

849p mebachano 01-02-2013 33 3   Download

Over the past three decades, considerable effort has been devoted to assessing the importance of spatial mismatch in determining racial and ethnic differences in employment outcomes. The hypothesis posits that persistent racial housing segregation in U.S. metropolitan areas coupled with the spatial decentralization of employment have left black and, to a lesser extent, Latino workers physically isolated from ever-important suburban employment centers.

31p nhacnenzingme 23-03-2013 35 3   Download