Alpha therapeutic

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract. Acquired functional mutations in the tyrosine-protein kinase growth factor receptor proto-oncogene (KIT) and platelet-derived growth factor-alpha gene lead to increased tyrosine kinase activity, which is considered a key factor in the pathogenesis of GIST.

14p vikoch 27-06-2024 1 1   Download

Therapeutic blockade of tumour necrosis factor alpha (anti-TNF-α) is the mainstay treatment of several rheumatologic diseases. They are unfrequently associated with opportunistic infections and latent tuberculosis (TB) screening is paramount before immunosuppression. A 62-year-old man with psoriatic arthritis was under treatment with adalimumab for over 5 years.

4p viintuit 26-09-2023 2 0   Download

Alnustone-like compounds are promising inhibitors for estrogen receptor α (ER-α), which is a novel cancer therapeutic target. Therefore, 10 alnustone-like compounds with substituents at the phenyl rings were synthesized by condensation of 4-phenyl-2-butanones and cinnamaldehydes via in situ enamination. The compounds displayed either protective activity or inhibited cell growth and proliferation of human breast cancer cells. Molecular docking studies indicated that the synthesized compounds interact with ER-α efficiently.

15p langthannam 29-12-2021 6 0   Download

Acute promyelocytic leukemia (APL) is a subset of acute myeloid leukemia (AML) which is characterized by the fusion of promyelocytic leukemia PML and retinoic acid receptor- alpha (RAR-alpha) genes. Alltrans retinoic acid (ATRA) and/or arsenic trioxide (ATO) have resulted in durable cytogenetic and molecular remissions in most APL patients and have altered the natural history of the disease.

9p vimahuateng 26-11-2021 9 1   Download

Numerous studies have implicated the aryl hydrocarbon receptor (AhR) as a potential therapeutic target for several human diseases, including estrogen receptor alpha (ERα) positive breast cancer. Aminoflavone (AF), an activator of AhR signaling, is currently undergoing clinical evaluation for the treatment of solid tumors.

16p virose2711 24-09-2020 16 0   Download

Embelin, a quinone derivative, is found in the fruits of Embelia ribes Burm (Myrsinaceae). It has been shown to have a variety of therapeutic potentials including anthelmintic, anti-tumor, anti-diabetic, anti-bacterial and anti-inflammation. Inflammation is an immunological response to external harmful stimuli and is regulated by an endogenous pyrogen and pleiotropic pro-inflammatory cytokine, tumor necrosis factor alpha (TNF-α).

12p vilisa271 22-09-2020 16 1   Download

About 75–80% of breast tumors express the estrogen receptor alpha (ER-α) and are treated with endocrine-target therapeutics, making this the premier therapeutic modality in the breast cancer clinic. However, acquired resistance is common and about 20% of resistant tumors loose ER-α expression via unknown mechanisms.

16p vimale2711 21-08-2020 13 1   Download

In patients with metastatic renal cell cancer, based on limited evidence, increased sunitinib exposure is associated with better outcome. The survival and toxicity data of patients receiving individualized dose escalated sunitinib therapy as compared to standard management were analyzed in this study.

12p vibaku2711 22-07-2020 17 2   Download

The incidence of papillary thyroid carcinoma (PTC) has been increasing worldwide in recent years. Therefore, novel potential therapeutic targets for PTC are urgently needed. Enhancer of zeste homolog 2 (EZH2), a methyltransferase belonging to PRC2, plays important roles in epigenetic silencing and cell cycle regulation.

9p vikuala271 13-06-2020 9 0   Download

Recombinant factor VIII (FVIII), used for haemophilia A therapy, is one of the most challenging among the therapeutic proteins produced in heterologous expression systems. Deletion variant of FVIII, in which the entire domain B is replaced by a short linker peptide, was approved for medical use.

15p vihamax2711 21-04-2020 17 2   Download

Hepatitis C virus (HCV) infected patients are known to be exposed to major liver complications i.e. cirrhosis and hepatocellular carcinoma. In addition, many extrahepatic manifestations including rheumatologic disorders have been reported in up to two-third of HCV infected patients. These manifestations include frank auto-immune and rheumatic diseases (such as arthralgia, myalgia, arthritis, sicca syndrome and vasculitis) which may dominate the course of infection.

9p kequaidan1 16-11-2019 14 0   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Therapeutic efficacy of alpha-1 antitrypsin augmentation therapy on the loss of lung tissue: an integrated analysis of 2 randomised clinical trials using computed...

8p toshiba11 19-10-2011 47 2   Download

TÁC DỤNG NGOẠI Ý Phản ứng dị ứng có thể xảy ra gây sốt, ớn lạnh, nổi mẩn, buồn nôn, ói mửa, tim đập nhanh và hạ huyết áp. Nếu phản ứng xảy ra, truyền chậm hoặc ngưng truyền có thể làm mất các triệu chứng trên. Nếu đã ngưng truyền và bệnh nhân đòi hỏi phải truyền ALBUMIN (NGƯỜI) U.S.P, ALBUTEIN, nên dùng sản phẩm của lô khác. ALBUTEIN, đặc biệt nếu truyền nhanh, có thể gây quá tải dẫn đến phù phổi. LIỀU LƯỢNG và CÁCH DÙNG ALBUTEIN dùng tiêm truyền tĩnh mạch. Tổng liều tùy từng cá...

5p thaythuocvn 27-10-2010 75 4   Download

CHỈ ĐỊNH ALBUTEIN 5% : 1. Điều trị sốc giảm thể tích. 2. Giảm albumin máu trầm trọng. Tuy nhiên dung dịch albumin chỉ điều trị triệu chứng, nên phối hợp với điều trị nguyên nhân. 3. Phụ trợ trong lọc thận nhân tạo và phẫu thuật có tuần hoàn ngoài cơ thể. Trong trường hợp đòi hỏi dịch keo nồng độ cao và ít cần dịch nên sử dụng loại 25%. ALBUTEIN 20% và 25% : 1. Điều trị sốc giảm thể tích. 2. Phụ trợ trong lọc thận nhân tạo cho bệnh nhân lọc thận dài ngày hoặc cho bệnh nhân bị quá...

5p thaythuocvn 27-10-2010 74 3   Download

c/o DIETHELM dung dịch tiêm tĩnh mạch 5% : chai 250 mL và 500 mL. dung dịch tiêm tĩnh mạch 20% : chai 50 mL và 100 mL. dung dịch tiêm tĩnh mạch 25% : chai 50 mL và 100 mL. THÀNH PHẦN cho 100 mL Albutein 5% 5 Albumin người g cho 100 mL Albutein 20% 20 Albumin người g cho 100 mL Albutein 25% 25 Albumin người g MÔ TẢ ALBUTEIN (NGƯỜI) U.S.P., ALBUTEIN 5%, 20% và 25% là dung dịch vô trùng tiêm tĩnh mạch đơn liều, gồm 3 loại chứa tương ứng 5%, 20% và 25% albumin người (trọng lượng/thể tích). ALBUTEIN được điều chế bằng...

5p thaythuocvn 27-10-2010 74 3   Download