AmpC β lactamase
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Bài viết Cập nhật sử dụng kháng sinh trong nhiễm khuẩn gram âm đa kháng theo hướng dẫn của IDSA 2023 trình bày việc lựa chọn kháng sinh điều trị các nhiễm khuẩn do ESBL-E (Enterobacterales sinh β-lactamase phổ mở rộng); Lựa chọn kháng sinh điều trị các nhiễm khuẩn do Enterobacterales sinh AmpC β-lactamase; Lựa chọn kháng sinh điều trị các nhiễm khuẩn do Enterobacterales kháng carbapenem.
11p vimichaelfaraday 14-12-2023 11 2 Download
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Administration of a competitive exclusion culture (CE culture) has the potential to induce protective effects in very young chicks against caecal colonisation by EEC (= extended-spectrum β-lactamases [ESBL] and AmpC-type [AmpC] beta-lactamases producing Escherichia coli).
7p vigalileogalilei 28-02-2022 23 1 Download
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To investigate a possible transmission of blaCMY-2 along the food production chain, we conducted a nextgeneration sequencing (NGS)-based analysis of 164 CMY-2-producing E. coli isolates from humans, livestock animals and foodstuff from Germany.
17p vitzuyu2711 29-09-2021 10 1 Download
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The study was aimed to detect the occurrence and characterize extended-spectrum (ESBL) and AmpC (ACBL) beta-lactamases producing pathogenic E. coli (STEC) in diarrhoeal faecal samples collected from bovines. All the E. coli strains (13/21, 61.9%) isolated from bovine diarrhoea cases (n=21) were found to be ESBL producers. In total, 11 (84.6%) isolates were positive in cefoxitin– cloxacillin double-disc synergy (CC-DDS) test for AmpC production and the isolates were also confirmed by PCR for blaAmpC.
11p chauchaungayxua10 19-03-2021 8 2 Download
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The aim of this study is to evaluate and comparing routinely phenotypic methods in detection of resistance with molecular methods. From this study, it can be concluded that cephamycin-Hodge test is the most sensitive, specific, interpretable and efficient test for detection of AmpC β-lactamases in clinical isolates of Proteus mirabilis, compared to the molecular method.
10p trinhthamhodang1218 26-02-2021 12 1 Download
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The present study was carried out to detect bacteria commonly associated in causation of VAP. Also to determine their antibiotic susceptibility patterns as well as to detect the presence of ESBL, AmpC β-lactamases, carbapenemases and MBL in these VAP pathogens.
8p cothumenhmong9 18-01-2021 8 0 Download
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The present study aimed to detect extended-spectrum beta-lactamases (ESBLs) and AmpC beta-lactamase (ACBL)-producing Escherichia coli from chicken meat, from different parts of West Bengal.
10p nguaconbaynhay7 15-08-2020 12 1 Download
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Enterobacteriaceae cause protean infections and are the common Gram negative isolates in a microbiology laboratory. Spectrum of multi-drug resistance includes AmpC, Extended spectrum beta lactamase and carbapenemase production with others. This was a cross sectional study to determine susceptibility pattern of AmpC and extended spectrum beta lactamase producing isolates against different antimicrobials.
10p chauchaungayxua6 26-06-2020 13 2 Download
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Increasing drug resistance due to the production of AmpC β-lactamases and Extended spectrum β-lactamases (ESBLs) is an increasing cause of concern as it has left the clinicians with limited therapeutic options. Aims were detection of AmpC β lactamase in E. coli an comparison of the two phenotypic tests- AmpC disk test and Inhibitor based test using phenyl boronic acid. A total of 156 E. coli isolates from various clinical samples were collected for the study.
6p nguaconbaynhay6 24-06-2020 21 2 Download
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The incidence of AmpC beta-lactamase producing K. pneumoniae has been steadily increasing over past years and is of significant concern as they restrict therapeutic options and cause treatment failure. The objective of the present study was to know the occurrence of AmpC beta-lactamase producing K. pneumoniae and to create a baseline antibiotic resistance data to implement effective antibiotic policy.
8p nguaconbaynhay6 24-06-2020 19 1 Download
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Acinetobacter the aerobic non fermenting GNCB are emerging as important pathogens in health care associated infection, exhibiting increased antimicrobial resistance by virtue of multiple resistant mechanisms with practically no therapeutic options. The objective was to determine the multitude of resistant mechanisms by phenotypic and genotypic characterization and the prevalent antimicrobial susceptibility pattern. 175 clinically significant non-duplicate Acinetobacter isolates were included.
10p nguaconbaynhay6 23-06-2020 12 1 Download
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Extended spectrum β-lactamases are often plasmid mediated and derived from mutations in bla-TEM, bla-SHV, bla-CTX-M, and bla-AmpC genes by one or more amino acid substitution around the active site. These genes are responsible for resistance to beta lactams in Pseudomonas aeruginosa. In this study, Pseudomonas aeruginosa were isolated from wound and burn infection patients admitted to Diwanyia Teaching Hospital.
7p gaocaolon5 14-06-2020 11 1 Download
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The aim of this study was to analyze the extended spectrum of β lactamase (ESBL), metallo β lactamase (MBL) and AmpC production in Pseudomonas aeruginosa in various clinical samples. A Total of 100 clinical isolates of P. aeruginosa were collected from different clinical specimen and confirmed by standard tests. Antibiotic susceptibility was determined by the Kirby-Bauer disc diffusion method. ESBL screening was done using 3rd generation cephalosporins and confirmatory combined double disc test, imipenem-EDTA double disc synergy test for MBL enzyme and AmpC test using Cefoxitin disc.
9p trinhthamhodang1213 30-05-2020 11 1 Download
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The prevalence of multi drug resistant gram negative bacteria has increased continuously over the past few years, of particular concern are strains producing AmpC β-lactamases. The irrational uses of antibiotics are the primary cause of the increase in drug resistant bacteria. Several studies have reported that AmpC producers are isolated mainly from patients with prolonged hospitalization, but certain recent studies have reported that AmpC producers was also isolated from long term care facilities and outpatient clinics, which indicate their presence in the community.
6p cothumenhmong5 17-05-2020 12 0 Download
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Critical care populations are at high risk for Multi drug resistant organisms (MDRO) colonization because of rampant use of broad-spectrum antibiotics leading to colonization with resistant strains, Screening for MDR organisms is one of the many approaches needed to deal with the very major clinical problem concerning drug resistance.
9p caygaocaolon4 01-04-2020 17 0 Download
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Gram-negative bacilli (GNB) are most frequently isolated bacteria from ascitic fluid aspirate of patients with Spontaneous bacterial peritonitis (SBP). Aetiology of SBP has been changing in recent years with increased involvement of multidrug resistant (MDR) bacteria as a result of production of various β-lactamases. The present study was done for detection of different β-lactamases and their co-existence by noveldisc placement method among GNB isolates from patients with SBP.
12p nguaconbaynhay3 07-02-2020 16 0 Download
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AmpC beta-lactamases hydrolyse penicillins, monobactams, cephalosporins and cephamycins. AmpC producers are resistant tobetalactam/betalactamase inhibitor combinations therapeutically. AmpC is generally underreported which leads to therapeutic failures and uncontrolled spread of these resistant strains. Hence, there is an increased need to detect AmpC routinely in the laboratory. To detect AmpC β-lactamase production among Enterobacteriaceae isolated from clinical samples and to compare different inducer substrate combinations for the detection of inducible Amp-C (iAmpC).
7p kethamoi2 15-12-2019 10 0 Download
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Ventilator-associated pneumonia (VAP) is an important nosocomial infection in mechanically ventilated patients at intensive care unit (ICU). The administration of accurate and timely initial empirical antibiotic therapy is essential to reduce the morbidity and mortality from Ventilator-associated pneumonia. Initial empiric antimicrobial therapy for VAP greatly depends on the type of causative pathogen and its resistance pattern. During the six months study period, 196 patients received mechanical ventilation.
7p cothumenhmong1 08-12-2019 19 1 Download
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Pseudomonas aeruginosa là một trong những căn nguyên phổ biến gây nhiễm trùng bệnh viện, nhiễm trùng cơ hội. Với các cơ chế đề kháng kháng sinh đa dạng như sinh β-lactamase phổ rộng, tăng cường sự biểu hiện của các gen mã hóa bơm đẩy, ức chế kênh porin, thay đổi tính thấm của màng…, P. aeruginosa đã gây ra rất nhiều khó khăn cho các bác sĩ lâm sàng trong việc lựa chọn phương pháp điều trị thích hợp. Trong nghiên cứu này, các tác giả sử dụng kỹ thuật multiplex PCR để phát hiện các gen mã hóa ESBL (blaVEB), MBL (blaDIM) và AmpC ở các chủng P.
5p camtucau99 14-11-2019 84 3 Download
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Trực khuẩn đường ruột đề kháng kháng sinh tăng lên một cách nhanh chóng trên toàn thế giới, kể cả các chủng chiếm cư đường tiêu hóa người lành mạnh. Thành phố Hồ chí Minh có rất ít nghiên cứu về vấn đề này, đặc biệt là E.coli và Klebsiella spp. chứa các gen kháng thuốc mã hóa enzym ESBL, AmpC, carbapenemase.
6p vihades2711 23-09-2019 17 0 Download