Amylase inhibition

Fractions yielded from Phellinus gilvus fruiting bodies by liquid-liquid partition of methanol extract contained various bioactive compounds such as phenolics, flavonoids and terpenes. Butanol, water and ethyl acetate fractions had large amount of phenolics, 158.12 - 247.31 mg of gallic acid equivalents (GAE)/g and low amount of flavonoids, 21.74 - 36.05 mg of quercetin equivalents (QE)/g.

9p vimelindagates 18-07-2022 11 3   Download

Two inhibitors, acarbose and cyclodextrins (CD), were used to investigate the active site structure and function of barleya-amylase isozymes, AMY1 and AMY2. The hydrolysis of DP 4900-amylose, reduced (r) DP18-malto-dextrin and maltoheptaose (catalysed by AMY1 and AMY2) was followed in the absence and in the presence of inhibitor. Without inhibitor, the highest activity was obtained with amylose,kcat /Kmdecreased 10 3 -fold using rDP18-maltodextrin and 10 5 to 10 6 -fold using maltohep-taose as substrate. ...

9p tumor12 20-04-2013 40 5   Download

Inhibitors targeting pancreatic a-amylase and intestinal a-glucosidases delay glucose production following digestion and are currently used in the treatment of Type II diabetes. Maltase-glucoamylase (MGA), a family 31 glycoside hydrolase, is ana-glucosidase anchored in the membrane of small intestinal epithelial cells responsible for the final step of mammalian starch digestion leading to the release of glucose.

11p inspiron33 26-03-2013 46 3   Download