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Analgesic strategy
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Epidural administration of morphine has been shown to be an effective analgesic strategy in horses; however, the possible occurrence of side effects limits its usage. In order to decrease their frequency, it is important to target the minimal effective plasma concentration and avoid overdosing.
5p
vigalileogalilei
28-02-2022
10
1
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The optimal perioperative analgesic strategy in video-assisted thoracic surgery (VATS) for anatomic lung resections remains an open issue. Regional analgesic concepts as thoracic paravertebral or epidural analgesia were used as systemic opioid application.
9p
vizhangzhidong
29-12-2021
11
0
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As a part of multimodal analgesia for laparoscopic cholecystectomy, both intraoperative lidocaine and esmolol facilitate postoperative analgesia. Our objective was to compare these two emerging strategies that challenge the use of intraoperative opioids. We aimed to assess if intraoperative esmolol infusion is not inferior to lidocaine infusion for opioid consumption after laparoscopic cholecystectomy.
9p
vizhangzhidong
29-12-2021
7
0
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Chronic non-specific low back pain is a major socioeconomic public health issue worldwide and, despite the volume of research in the area, it is still a difficult-to-treat condition. The conservative analgesic therapy usually comprises a variety of pharmacological and non-pharmacological strategies, such as transcutaneous electrical nerve stimulation.
8p
vianttinic2711
20-04-2021
12
1
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Transpedicular intracorporeal cement augmentation (TCA) with short segmental posterior instrumentation (SSPI), which provides an ideal immediate analgesic effect and long-term reconstructive stability, is thought to be a sensible advancement to the operative strategy in treating osteonecrosis of the vertebral body (ONV). However, longterm follow-up studies about the treatment are scarce.
7p
vivermont2711
28-01-2021
20
1
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Reduce hiv risk and vulnerability in settings of humanitarian concern. Contingency plans for essential HIV services should be part of national HIV plans in order to ensure continuity of HIV treatment and care in settings of humanitarian concern, including buffer stocks of essential medicines and commodities (including antiretroviral medicines, condoms, diagnostic assays, opioid analgesics and sterile injecting supplies).
67p
nhamnhiqa
01-03-2013
50
1
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With publication of the human genome has come an experiment in reductionism for drug discovery. With the evaluation of the number and quality of new drug treatments from this approach has come a reevaluation of target-based versus systems-based strategies. Pharmacology, historically rooted in systems-based approaches and designed to give systems-independent measures of drug activity, is suitably poised to be a major (if not the major) tool in this new environment of drug discovery.
294p
mnemosyne75
02-02-2013
36
4
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In the treatment of bone pain, the second step on the WHO analgesic ladder is commonly unhelpful, with inadequate pain relief or the development of undesirable/intolerable side-effects (Eisenberg, 2005). There is currently no place for interventional treatment on the ladder and the earlier recommendations of a fourth step of interventional management are not applied widely enough. The main principles of pain management, including the use of a biopsychosocial approach, should be applied, rather than simply following the WHO ladder.
0p
khongmuonnghe
07-01-2013
49
1
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A major unmet clinical need exists for long-acting neurotherapeutics to alleviate chronic pain in patients unresponsive to available nonaddictive analgesics. Herein, a new strategy is described for the development of potent and specific inhibitors of the neuronal exocytosis of transmitters and pain mediators that exhibit unique antinociceptive activity.
13p
cosis54
09-12-2012
44
2
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