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Báo cáo khoa hoc : Novel therapeutics based on recombinant botulinum neurotoxins to normalize the release of transmitters and pain mediators
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A major unmet clinical need exists for long-acting neurotherapeutics to alleviate chronic pain in patients unresponsive to available nonaddictive analgesics. Herein, a new strategy is described for the development of potent and specific inhibitors of the neuronal exocytosis of transmitters and pain mediators that exhibit unique antinociceptive activity.
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