Nervous system

The process of neural stem cell (NSC) differentiation into neurons is crucial for the development of potential cell-centered treatments for central nervous system disorders. However, predicting, identifying, and anticipating this differentiation is complex. In this study, we propose the implementation of a convolutional neural network model for the predictable recognition of NSC fate, utilizing single-cell brightfield images.

7p viengfa 28-10-2024 1 1   Download

This study was conducted to investigate the residual of Chlorpyrifos (CPF) in coffee growing soil at Lam Ha district, Lam Dong province. Fifteen soil samples were collected from coffee intensive gardens in the Phi To, Nam Ha, Me Linh and Dong Thanh communes of Lam Ha district during the February 2023.

9p vibecca 01-10-2024 2 1   Download

Drug therapy to achieve the recommended target blood pressure remains the cornerstone of the management of hypertension. Today, there are strong evidences from randomized controlled trials that antihypertensive drugs are more effective than placebo at reducing cardiovascular mortality and morbidity.

8p vifaye 20-09-2024 3 1   Download

Bacterial infections have a substantial impact on global health and can become serious if misdiagnosed with several diseases related to the central nervous, cardiovascular, and respiratory systems. The prognosis in patients with infectious disease strongly depends on early diagnosis and appropriate antibiotic therapy.

8p vifaye 20-09-2024 3 1   Download

In this study, a computational investigation of the physicochemical properties of hypericin and pseudohypericin revealed drug-like characteristics. Pharmacokinetic predictions indicated that hypericin and pseudohypericin are non-toxic to the central nervous system, hepatic system, and cardiac system. Molecular docking results indicated a strong binding affinity of hypericin/pseudohypericin with MPXV thymidylate kinase. As a result, these compounds are being considered as potential Mpox control candidates.

11p xuanphongdacy06 18-09-2024 3 1   Download

In this study, we aim to investigate the serum glucose level in children with epilepsy. Method: A cross-sectional study was conducted at the Pediatric Center of Hue Central Hospital between June 2017 and June 2019. A serum glucose level test was performed after the seizure.

4p vinatisu 29-08-2024 1 1   Download

The aims of the study "Characterising microbial and neuroimmune interactions in a mouse model of autism" are threefold: i) To characterize the influence of the R451C mutation on caecal enteric neuron organization; ii) To characterize the influence of the R451C mutation on caecal patch macrophage density and morphology; iii) To assess for alterations in gut microbes in different regions of the GI tract in the NL3R451C mouse model of autism.

83p runthenight04 02-02-2023 7 1   Download

"Master's thesis of Science: Intestinal permeability and functional properties of duodenal enteric neurons in a mouse model of autism" is structured as follows: Chapter 1: Introduction; Chapter 2: Measuring intestinal permeability in the Neuroligin-3R451C mouse model of autism; Chapter 3: Optimisation of the patch-clamp recording technique in the enteric nervous system to examine action potential characteristics in mouse duodenal myenteric neurons.

147p runthenight04 02-02-2023 10 3   Download

Melanoma-intrinsic activated β-catenin pathway, the product of the catenin beta 1 (CTNNB1) gene, has been associated with low/absent tumor-infiltrating lymphocytes, accelerated tumor growth, metastases development, and resistance to anti-PD-L1/anti-CTLA-4 agents in mouse melanoma models.

14p vielonmusk 21-01-2022 10 0   Download

High-dose methotrexate (HD-MTX) has broad use in the treatment of central nervous system (CNS) malignancies but confers significant toxicity without inpatient hydration and monitoring. Glucarpidase is a bacterial recombinant enzyme dosed at 50units (u)/kg, resulting in rapid systemic MTX clearance.

10p vielonmusk 21-01-2022 15 1   Download

It is unknown whether and to what degree trials submitted to the US FDA to support drug approval adhere to NCCN guideline-recommended care in their baseline and surveillance CNS imaging protocols. Objective: We sought to characterize the frequency with which the trials cited in US FDA drug approvals for first line advanced NSCLC between 2015 and 2020 deviated from NCCN guideline-recommended care for baseline and surveillance CNS imaging.

8p vielonmusk 21-01-2022 13 0   Download

Regulators of G protein signaling (RGS) proteins modulate G protein-coupled receptor (GPCR) signaling networks by terminating signals produced by active Gα subunits. RGS17, a member of the RZ subfamily of RGS proteins, is typically only expressed in appreciable amounts in the human central nervous system, but previous works have shown that RGS17 expression is selectively upregulated in a number of malignancies, including lung, breast, prostate, and hepatocellular carcinoma.

10p caothientrangnguyen 09-05-2020 12 0   Download

Regulator of G protein signaling (RGS) proteins are gatekeepers regulating the cellular responses induced by G protein-coupled receptor (GPCR)-mediated activation of heterotrimeric G proteins. Specifically, RGS proteins determine the magnitude and duration of GPCR signaling by acting as a GTPase-activating protein for Gα subunits, an activity facilitated by their semiconserved RGS domain. The R7 subfamily of RGS proteins is distinguished by two unique domains, DEP/DHEX and GGL, which mediate membrane targeting and stability of these proteins.

13p caothientrangnguyen 09-05-2020 24 1   Download

Regulator of G-protein signaling (RGS) proteins were originally identified as negative regulators of G-protein-coupled receptor (GPCR) signaling via their GTPase-accelerating protein (GAP) activity. All RGS proteins contain evolutionarily conserved RGS domain; however, they differ in their size and regulatory domains. RGS1 and RGS10 are smaller than other RGS proteins, and their functions involve various inflammatory responses including autoimmune responses in both the periphery and the central nervous system (CNS). Neuroinflammation is the chronic inflammatory response in the CNS.

5p caothientrangnguyen 09-05-2020 24 1   Download

This chapter students will be able to: List the basic functions of the nervous system; explain the structural and functional divisions of the nervous system; list the types of neuroglia and cite their functions; define neuron, describe its important structural components, and relate each to a functional role;...

47p tangtuy07 02-04-2016 46 2   Download

Chapter 11 - Fundamentals of the nervous system and nervous tissue (part b). In this chapter, you will learn: Define resting membrane potential and describe its electrochemical basis, compare and contrast graded potentials and action potentials, explain how action potentials are generated and propagated along neurons,...

55p tangtuy07 02-04-2016 42 2   Download

In this chapter, students will be able to understand: Define synapse, distinguish between electrical and chemical synapses by structure and by the way they transmit information, distinguish between excitatory and inhibitory postsynaptic potentials, describe how synaptic events are integrated and modified,...

80p tangtuy07 02-04-2016 31 2   Download

Chapter 12 - The central nervous system (part a), the topics discussed in this chapter are: Central Nervous System (CNS), embryonic development, effect of space restriction on brain development, regions and organization of the CNS, ventricles of the brain,...and other contents.

60p tangtuy07 02-04-2016 38 2   Download

Chapter 12 - The central nervous system (part b), this chapter includes contents: Lateralization of cortical function, cerebral white matter, basal nuclei (ganglia), functions of basal nuclei, diencephalon, thalamus, thalamic function, hypothalamic function,...

45p tangtuy07 02-04-2016 42 2   Download

Chapter 12 - The central nervous system (part c), in this chapter you will learn about the following: Functional brain systems, limbic system, limbic system: emotion and cognition, reticular formation, reticular formation: RAS and motor function, electroencephalogram (EEG), brain waves,...and other contents.

63p tangtuy07 02-04-2016 39 2   Download