Anaplastic astrocytomas

Chromosomal rearrangements occur constitutionally in the general population and somatically in the majority of cancers. Detection of balanced rearrangements, such as reciprocal translocations and inversions, is troublesome, which is particularly detrimental in oncology where rearrangements play diagnostic and prognostic roles.

11p vialfrednobel 29-01-2022 16 0   Download

Members of the genus Myroides namely, M. odoratus and M. odoratimimus are ubiquitous in nature. Over past decade, these Gram negative bacteria are increasingly being implicated in various life threatening infections in health care setting. Here we report a case of urosepsis due to multi-drug resistant M. odoratimimus in a 41 year old male with anaplastic astrocytoma. The case highlights the importance of surveillance of multidrug resistant organisms in intensive care units of hospital.

6p nguathienthan8 20-10-2020 7 1   Download

Today, the treatment of choice for high- and low-grade gliomas requires primarily surgical resection to achieve the best survival and quality of life. Nevertheless, many gliomas within highly eloquent cortical regions, e.g., insula, rolandic, and left perisylvian cortex, still do not undergo surgery because of the impending risk of surgery-related deficits at some centers.

11p vijisoo2711 29-09-2020 14 1   Download

The prognosis of patients bearing high grade glioma remains dismal. Epidermal Growth Factor Receptor (EGFR) is well validated as a primary contributor of glioma initiation and progression. Nimotuzumab is a humanized monoclonal antibody that recognizes the EGFR extracellular domain and reaches Central Nervous System tumors, in nonclinical and clinical setting.

8p vijennie2711 29-09-2020 10 0   Download

Pleomorphic xanthoastrocytoma (PXA) is a rare WHO grade II tumor accounting for less than 1% of all astrocytomas. Malignant transformation into PXA with anaplastic features, is unusual and correlates with poorer outcome of the patients.

11p virose2711 25-09-2020 10 1   Download

Astrocytomas are the most common primary brain tumors distinguished into four histological grades. Molecular analyses of individual astrocytoma grades have revealed detailed insights into genetic, transcriptomic and epigenetic alterations. This provides an excellent basis to identify similarities and differences between astrocytoma grades.

22p vimoscow2711 29-08-2020 14 1   Download

Co-occurrence of multiple sclerosis (MS) and glial tumours (GT) is uncommon although occasionally reported in medical literature. Interpreting the overlapping radiologic and clinical characteristics of glial tumours, MS lesions, and progressive multifocal leukoencephalopathy (PML) can be a significant diagnostic challenge.

11p vidhaka2711 31-07-2020 12 1   Download

Several efforts have been focused on identification of pathways involved in malignancy, progression, and response to treatment in Glioblastoma (GB). Overexpression of PKCε was detected in histological samples from GB, anaplastic astrocytoma, and gliosarcoma and is considered an important marker of negative disease outcome.

17p vibaku2711 22-07-2020 14 1   Download

Astrocytomas are the most common malignant glial tumors. With improved prognosis, it is possible for patients to pursue pregnancy post-treatment. However, with potential gonadotoxicity of oncology treatments, fertility preservation prior to chemotherapy and/or radiation therapy should be considered.

4p vibaku2711 22-07-2020 10 2   Download

(bq) part 1 book "brain tumors" presentation of content: normal tissue, recurrent high grade glioma with radiation changes, gemistocytic astrocytoma, anaplastic astrocytoma, glioblastoma multiforme, granular cell glioblastoma, giant cell glioblastoma, pleomorphic xanthoastrocytoma, pilomyxoid astrocytoma,... and other content.

152p thangnamvoiva23 06-10-2016 40 4   Download