Antagonists

Luận án "Nghiên cứu hiệu quả của phác đồ kích thích buồng trứng flare-up và antagonist trên bệnh nhân có tiên lượng đáp ứng kém trong thụ tinh ống nghiệm" được hoàn thành với mục tiêu nhằm đánh giá hiệu quả của phác đồ kích thích buồng trứng flare-up và antagonist trên bệnh nhân có tiên lượng đáp ứng kém trong thụ tinh ống nghiệm; Phân tích một số yếu tố liên quan đến hai phác đồ trên.

186p bapxao06 09-03-2023 22 9   Download

Foot rot of tomato is an important disease which causes severe loss in tomato production. The present study was carried out to evaluate five bioagents and six fungicides against Sclerotium rolfsii. Among the five antagonists tested the maximum inhibition was observed in Trichoderma virens (67%) and contrarily, no inhibition was observed in Bacillus subtilis. Six fungicides viz., carbendazim, captan, tebuconozole, copper oxychloride, hexaconozole and Tebuconazole +Trifloxytrobin at different concentrations (50, 100, 150, 200, 250 and 500 ppm), were tested.

8p chauchaungayxua6 26-06-2020 18 4   Download

Objectives of the thesis: Identifying the Meloidogyne species causing damage on main crops in Tay Nguyen Highlands. Analyze the diversity of Meloidogyne species based on morphology and molecular classification. Assessing the preventative ability of antagonistic microorganisms to Meloidogyne incognita in laboratory condition.

27p xacxuoc4321 08-07-2019 36 5   Download

The objectives of the thesis: To identify species composition of PPNs on carrots in major carrot growing areas in Vietnam. To determine the parasitic nematode group causing significant damage to carrots in the studied areas. To evaluate the ability to control some important PPNs on carrots by using antagonistic fungi in the laboratory conditions.

27p xacxuoc4321 09-07-2019 61 4   Download

The octadecaneuropeptide (ODN; QATVGDVNTDRPG LLDLK) and its C-terminal octapeptide (OP; RPGLLDLK), which exert anxiogenic activity, have been previously shown to increase intracellular calcium concentration ([Ca21]i) in cultured rat astrocytes through activation of a metabotropic receptor positively coupled to phospholipase C. It has also been found that the [D -Leu5]OP analog possesses a weak antagonistic activity. The aim of the present study was to synthesize and characterize cyclic analogs of OP and [D -Leu5]OP.

13p system191 01-06-2013 32 4   Download

TheDrosophila melanogasterprotein sprouty is induced uponfibroblast growth factor (FGF)- andepidermal growth factor (EGF)-receptor tyrosine kinase activation and acts as an inhibitor of the ras/MAP kinase pathway downstreamof these receptors. By differential displayRT-PCRof activated vs. resting umbilical artery smooth muscle cells (SMCs) we detected a new human sprouty gene, which we designated human sprouty 4 (hspry4) based on its homology with murine sprouty 4.

11p research12 29-04-2013 45 2   Download

Serotonin transporters are key target sites for clinical drugs and psychostimulants, such as fluoxetine and cocaine. Molecular cloning of a serotonin transporter from the cen-tral nervous system of the insectManduca sextaenabled us to define domains that affect antagonist action, particularly cocaine.

11p research12 23-04-2013 35 1   Download

Previous structural andmutagenesis studies indicate that the invariant a-amino and a-carboxyl groups of glutamate receptor agonists are engaged in polar interactions with oppositely charged, conserved arginine and glutamate resi-dues in the ligand-binding domain ofa-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor.To examine the role of these residues (R507 and E727 in the GluR-D subunit) in the discrimination between agonists and anta-gonists, we analyzed the ligand-binding properties of homomeric GluR-D and its soluble ligand-binding domain withmutations at thesepositions....

10p tumor12 22-04-2013 38 3   Download

A new human/rat CRH analogue has been synthesized using the Fmoc/tBu solid-phase synthetic protocol. The sequence ofthe new peptide differs from the original in two positions, 12 and 15, at which the native amino acids L-phenylalanine 12 and L-leucine 15 have been replaced by the nonprotein amino acids D-phenylalanine and a-aminoisobutyric acid (Aib), respectively. The high resolution three-dimensional solution structure of [D-Phe12, Aib15]CRH has been determined by 688 dis-tance constraints (656 meaningful NOE and 32 H-bonds distance limits) and 21 angle constraints. ...

11p tumor12 22-04-2013 34 3   Download

Anovel photoactivatable analog of antisauvagine-30 (aSvg-30), a specific antagonist for corticotropin-releasing factor (CRF) receptor, type 2 (CRF2), has been synthesized and characterized. TheN-terminal amino-acidD-Phe in aSvg-30 [D-Phe11,His12]Svg(11)40) was replacedbyaphenyldiazirine, the 4-(1-azi-2,2,2-trifluoroethyl)benzoyl (ATB) residue.

7p tumor12 22-04-2013 32 3   Download

Intraperitoneal injection of choline (30–90 mgÆkg )1 ) produced a dose-dependent increase in serum insulin, glu-cose and choline levels in rats.The increase in serum insulin induced by choline (90 mgÆkg )1 ) was blocked by pretreat-mentwith themuscarinic acetylcholine receptor antagonists, atropine (2 mgÆkg )1 ), pirenzepine (2 mgÆkg )1 ) and 4-diphe-nylacetoxy-N-methylpiperidine (2 mgÆkg )1 ) or the gangli-onic nicotinic receptor antagonist, hexamethonium (15 mgÆkg )1 ).

9p tumor12 20-04-2013 45 3   Download

Post ischaemic cell calcium invasion has been described as one of the main causes of graft failure. Protective effects of calcium antagonists have been investigated but are not con-vincing and their mechanisms of action remain unclear. In this work we tested the protective effect of a new calcium inhibitor described to block a calcium current insensitive to all known calcium blockers. Specific mapacalcine receptors were first characterized on rat hepatocytesmembranes using the 125 I-labeledmapacalcine....

6p fptmusic 16-04-2013 35 3   Download

Defining how the agonist–receptor interaction differs from that of the antagonist–receptor and understanding the mechanisms of receptor activation are fundamental issues in cell signalling. The V1a vasopressin receptor (V1aR) is a member of a family of related G-protein coupled receptors that are activated by neurohypophysial peptide hormones, including vasopressin (AVP). It has recently been reported that anarginyl in the distalN-terminus of theV1a Riscritical for binding agonists but not antagonists....

8p fptmusic 12-04-2013 28 2   Download

Sir John Vane named vascular endothelium ‘the maestro of blood circula-tion’. Recently, ‘the maestro’ has become a target for pharmacotherapy of atherothrombotic and diabetic vasculopathies with well known cardio-vascular drugs belonging to the families of Angiotensin Converting Enzyme inhibitors, HMG CoA reductase inhibitors or b1 -Adrenoceptor antagonists. These drugs became upgraded to a position of the pleiotropic endothelial drugs.

12p fptmusic 11-04-2013 39 3   Download

Aedes aegyptikynurenine aminotransferase (AeKAT) catalyzes the irrevers-ible transamination of kynurenine to kynurenic acid, the natural antagonist of NMDA and 7-nicotinic acetycholine receptors. Here, we report the crys-tal structure of AeKAT in its PMP and PLP forms at 1.90 and 1.55 A ˚ , respectively. The structure was solved by a combination of single-wave-length anomalous dispersion and molecular replacement approaches.

9p awards 06-04-2013 38 2   Download

Trichodermaspecies have been investigated as biological control agents for over 70 years owing to their ability to antagonize plant pathogenic fungi. Mycoparasitism, one of the main mechanisms involved in the antagonistic activity ofTrichodermastrains, depends on the secretion of complex mix-tures of hydrolytic enzymes able to degrade the host cell wall. The antifun-gal activity of an a-1,3-glucanase (EC 3.2.1.59, enzymes able to degrade a-1,3-glucans and also named mutanases) has been described in T. harzia-num and its role in mycoparasitic processes has been suggested....

0p awards 05-04-2013 44 4   Download

Lipopolysaccharide (LPS) from the outer membrane of Gram-negative bac-teria belongs to the most potent activators of the mammalian immune sys-tem. Its lipid moiety, lipid A, the ‘endotoxic principle’ of LPS, carries two negatively charged phosphate groups and six acyl chain residues in a defined asymmetric distribution (corresponding to synthetic compound 506). Tetraacyl lipid A (precursor IVa or synthetic 406), which lacks the two hydroxylated acyl chains, is agonistically completely inactive, but is a strong antagonist to bioactive LPS when administered to the cells before LPS addition. .

14p awards 05-04-2013 28 2   Download

Experimental autoimmune encephalomyelitis can be induced in susceptible animals by immunodominant deter-minants of myelin basic protein (MBP). To characterize the molecular features of antigenic sites important for designing experimental autoimmune encephalomyelitis suppressing molecules, we report structural studies, based on NMR experimental data in conjunction with molecular dynamic simulations, of the potent linear dodecapeptide epitope of guinea pig MBP, Gln74-Lys75-Ser76-Gln77-Arg78-Ser79-Gln80-Asp81-Glu82-Asn83-Pro84-Val85 [MBP(74–85)], and its antagonist analogue Ala81MBP(74–85)....

15p awards 05-04-2013 54 3   Download

A protocol to follow the processing of angiotensin I into angiotensin II by rabbit angiotensin-converting enzyme (ACE) and its inhibition by a novel natural antagonist, the leech osmoregulator factor (LORF) using capillary zonal electrophoresis is described. The experiment was carried out using the Beckman PACE system and steps were taken to determine (a) the migration profiles of angiotensin and its yielded peptides, (b) the minimal amount of angiotensin II detected, (c) the use of different electrolytes and (d) the concentration of inhibitor. ...

6p dell39 03-04-2013 44 4   Download

The recent discovery of theNogo family ofmyelin inhibitors and theNogo-66 receptor opens upa very promising avenue for the development of therapeutic agents for treating spinal cord injury. Nogo-A, the largest member of the Nogo fam-ily, is a multidomain protein containing at least two regions responsible for inhibiting central nervous system (CNS) regeneration. So far, no structural information is available for Nogo-A or any of its structural domains. We have sub-cloned and expressed two Nogo-A fragments, namely the 182 residueNogo-A(567–748) and the 66 residueNogo-66 in Escherichia coli..

11p dell39 03-04-2013 48 4   Download